Under construction – not a live service
Sign in
Taking people in ItalyNo phase

Studies glutamate in brain tumor samples from adults with glioblastoma

Collects blood, spinal fluid and tumor samples from adults with glioblastoma, a brain tumor.

Plain-language title generated from the registry record
Registry title: Glutamate Excitotoxicity and Its Role in Glioblastoma Biology

Key facts

Where
Milan, ItalySee the site

Where in Italy

  • IRCCS San Raffaele Scientific InstituteMilan, ItalyTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
IRCCS San Raffaele
Trial code
NCT05775458
Record updated
11 June 2025
Original description
Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasionRead full original descriptionShow less

Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme

Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion

Inclusion: Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant); Patient able to provide informed consent.

Exclusion: Liver disease; Age < 18 years; Severe anemia (Hb <8mg/dl); Pregnancy.

ClinicalTrials.gov NCT05775458