NCT05780775Active, not recruiting

Lipid Balance in Adult Sickle Cell Patients

Study of Lipid Balance in Adult Sickle Cell SS or SC Patients at Steady State and According to Clinical Phenotypes and During Acute Complications Acronym : "HDL2"

Source: ClinicalTrials.gov · Last updated 10 Dec 2025

Brief summary (registry, in English)

This study aims to describe and/or searches for, in cohorts of adult sickle cell anemia (SCA) and SC sickle cell patients living in the French West Indies and followed by SCD Reference and Competence Centers: 1-lipids profiles and associations at steady state with occurrence of sickle cell disease (SCD) complications, 2-lipids profile evolution during and after prospective acute complications (vasoocclusive crises (VOC) and priapism), 3-lipids profile variation (inter /intra individuals) during 4 prospective years, 4- Genetic primary modulators of SCD complications, 5- insulin resistance (HOMA), free fatty acids and glycerol dosages, 6- lipids enzymes, lipidome and functionality of HDL in sub-groups of SCD population.

Status (registry): Active, not recruiting
Study type: Interventional
Enrollment: 116 (actual)
First submitted: 12 Dec 2022
Start date: 30 Nov 2022
Primary completion date: 30 Nov 2027
Lead sponsor: Centre Hospitalier Universitaire de la Guadeloupe
Diseases: Sickle cell disease, Pulmonary arterial hypertension, High blood pressure
NCT number: NCT05780775

What you commit to

Study type: Interventional
Participants enrolled: 116
From 30 Nov 2022 to the primary completion date, 30 Nov 2027
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

Other hemoglobinopathies than sickle cell disease
Patient hospitalized for transfusion or bleeding in the last 3 months

Other

Pregnancy or lactation
Patient under judicial protection or without freedom
Patient not affiliated with a social security system

Who the study is looking for

Aged from 18 years and over
Be affected with Sickle cell anemia or SC sickle cell
Living in French Caribbean Islands of Guadeloupe or Martinique and followed by physicians issued from a French West Indies Sickle Cell Reference or Competence Center
At steady state in the last month (without acute complication)
To have given a written consent after information on the study.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
Unité Transversale de la Drépanocytose Coordinator of this site? Confirm its status	Pointe-à-Pitre	Guadeloupe	Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.