Tests high-intensity interval training in people with axial spondyloarthritis
Tests high-intensity interval exercise with coaching in adults with axial spondyloarthritis.
Plain-language title generated from the registry record
Registry title: High-intensity Training in Patients With Spondyloarthritis: a Randomized Controlled Trial
Key facts
- Where
- Halmstad, SwedenSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 67 with axial spondyloarthritis who already follow physical activity recommendations. It tests high-intensity interval training against usual exercise.
- Age
- 18 to 67 years
- Sex
- All sexes can join.
- Disease stage
- Axial spondyloarthritis (ICD10 diagnosis of M45, M46.0, M46.1, M46.8 or M46.9).
- Earlier treatment
- TNF or anti-inflammatory medication must not have changed in the previous three months. People must not do high-intensity interval training regularly.
Main reasons for not taking part
- Changed TNF or anti-inflammatory medication in the previous three months
- Cardiovascular disease
- Other illnesses that make high-intensity training inappropriate
- Doing high-intensity interval training on a regular basis
Read by machine on 11 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 67 years old?
Source: NCT05781763, who can take part
Where in Sweden
- Halmstad UniversityHalmstad, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Halmstad University
- Trial code
- NCT05781763
- Record updated
- 23 March 2023
- Original description
Project summaryRead full original descriptionShow less
High-intensity Exercise Based on Self-management With Digital Coaching in Patients With Spondyloarthritis: a Randomized Controlled Trial
Project summary
Background: For people diagnosed with a spondyloarthritis (SpA) e.g. ankylosing spondylitis or undifferentiated spondyloarthritis, physical activity and exercise are important components in the self-management. Exercise, in addition to physical and mental symptoms related to the disease can easily feel overwhelming to exercise, and low adherence may result. By studying the effects of high-intensity interval training (HIIT) in comparison with training as usual on physiological, inflammatory, and self-reported disease parameters in patients with SpA, we intend to further investigate the short-term and longitudinal training effects, and refine the knowledge to tailor, coach, and stimulate to self-performed HIIT.
Objective: The purpose of this study is to investigate the short- and long-term effects of high- intensity interval training (HIIT) on physiological, inflammatory, and self-reported health parameters in patients with SpA. The aim is also to study the adherence to physical activity and exercise recommendations.
Design: A randomized controlled trial (RCT) design. Participants: One hundred adults with a confirmed axial SpA from rheumatology clinics in southern Sweden will be recruited and randomized into two groups, the intervention group and the control group.
Intervention: Three high-intensity training sessions per week for three months, of which two interval sessions, with coaching both from a clinical physiotherapist and digital devices (watch and app) followed by nine months with sporadic coaching. The control group will go on with exercise as usual.
Primary outcome: Self-reported disease activity, inflammatory biomarkers (acute phase proteins).
Secondary outcomes: Physical fitness (aerobic capacity (VO2max), blood pressure, grep strength), body composition and self-reported physical function, health status, well-being, pain, fatigue, adherence to physical activity and exercise recommendations, and confidence in one's own ability to manage pain, symptoms and high-intensity exercise, and additional serum biomarkers.
Inclusion: Axial SpA (ICD10 diagnosis of M45, M46.0, M46.1, M46.8 and M46.9); Fulfilling recommendations for physical activity.
Exclusion: Changed TNF and anti-inflammatory medication the previous three months; Cardiovascular disease; Comorbidities making high-intensity training inappropriate; Performing high-intensity interval training on a regular basis.