Taking people in GermanyNo phase
Compares two stenting approaches in heart attack patients with multivessel coronary disease
Tests treating all narrowed heart arteries versus only the artery causing the heart attack.
Key facts
- Who runs it
- Leipzig Heart Science gGmbH
- Where
- Bad Berka, Bad Krozingen, Bad Nauheim, Bad Oeynhausen, Berlin, Bielefeld, Bochum, Bremen, Dessau, Dortmund, Dresden, Düsseldorf, Erfurt, Erlangen, Essen, Freiburg im Breisgau, Fulda, Giessen, Göttingen, Greifswald, Halle, Hamburg, Heidelberg, Homburg, Jena, Karlsruhe, Kiel, Langen, Leipzig, Lübeck, Ludwigshafen, Magdeburg, Mannheim, Marburg, München, Neumarkt, Nuremberg, Oldenburg, Plauen, Regensburg, Rostock, Schwerin, Trier, Tübingen, Villingen-Schwenningen, Wolfenbüttel, and Wuppertal, GermanySee the 55 sitesAlso in 1 other country, 3 sites
- Trial code
- Registry title
- Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI
- Status
- Recruiting
- People taking part
- 3,390 people, planned
- Started
- 27 Oct 2023
- Expected to end
- 31 Jul 2027
- Type of study
- Interventional, 2 groups
- Treatments tested
- Culprit-lesion revascularization
- Non-culprit-lesion revascularization
- Record updated
- 16 January 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a heart attack of the NSTEMI type who also have narrowed arteries in more than one heart vessel and one clearly identified culprit lesion.
- Age
- 18 years and older
- Sex
- All sexes can join.
- Disease stage
- NSTEMI (a heart attack without ST-segment elevation, suggested by high-sensitivity troponin tests), with coronary artery disease in more than one vessel and an identifiable culprit lesion.
- Earlier treatment
- People who have had a coronary artery bypass graft cannot join.
- Biomarker or test result
- NSTEMI as suggested by high-sensitivity troponin algorithms.
Main reasons for not taking part
- Cardiogenic shock
- Sustained ventricular tachycardia (VT) or ventricular fibrillation (VF)
- Prior coronary artery bypass graft, or an indication for bypass surgery
- Non-culprit lesion in the left main coronary artery
- Pregnancy or breast feeding
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- NSTEMI as suggested by high-sensitivity troponin algorithms
- Multivessel coronary artery disease
- Identifiable culprit lesion
- Informed consent
Who cannot take part
- Prior coronary artery bypass graft
- Indication for coronary artery bypass graft surgery
- Type 2 myocardial infarction
- Age <18 years
- Cardiogenic shock
- Sustained ventricular tachycardia (VT) or ventricular fibrillation (VF)
- Contraindication for coronary revascularization
- Non-culprit lesion located in the left main coronary artery
- Co-morbidity with life expectancy less than 6 months
- Pregnancy and breast feeding period
Where in Germany
Also in 1 other country, 3 sites
- Zentralklinik Bad Berka, Klinik für KardiologieBad Berka, GermanyContact: Philipp Lauten, MDTaking people
- Universitäts-Herzzentrum Bad Krozingen, Klinik für Kardiologie und AngiologieBad Krozingen, GermanyContact: Miroslaw Ferenc, MDNot yet recruiting
- Kerckhoff-KlinikBad Nauheim, GermanyContact: Maren Weferling, MDTaking people
- Herz- und Diabeteszentrum NRW, Universitätsklinikum der Ruhr-Universität Bochum, Klinik für Allgemeine und Interventionelle Kardiologie/AngiologieBad Oeynhausen, GermanyContact: Regine Brinkmann, MDTaking people
- BG Klinikum Unfallkrankenhaus Berlin gGmbH, Klinik für Innere Medizin/KardiologieBerlin, GermanyContact: Sebastian Winkler, MDTaking people
- Charité - University Medicine Berlin, Department of Internal Medicine and Cardiology, Campus Virchow KlinikumBerlin, GermanyContact: Tobias Trippel, MDNot yet recruiting
- Klinikum Bielefeld gem. GmbH, Klinik für Kardiologie und Internistische IntensivmedizinBielefeld, GermanyContact: Christoph Stellbrink, MDTaking people
- Klinik für Kardiologie und Rhythmologie, St. Josef Hospital, Universitätsklinikmum der Ruhr-Universität BochumBochum, GermanyContact: Arash Haghikia, MDNot yet recruiting
- Klinikum Links der Weser, Innere Medizin IIBremen, GermanyContact: Harm Wienbergen, MDTaking people
- Städtisches Klinikum Dessau; Klinik für Innere Medizin II (Kardiologie, Angiologie, Diabetologie, internistische Intensivmedizin)Dessau, GermanyContact: Georg Fürnau, MDNot yet recruiting
- St. Johannes Hospital, Klinik für Innere Medizin IDortmund, GermanyContact: Helge Möllmann, MDTaking people
- Herzzentrum Dresden GmbH Universitätsklinik an der Technischen Universität Dresden, Klinik für Innere Medizin und KardiologieDresden, GermanyContact: Axel Linke, MDTaking people
- Heinrich Heine Universitätsklinikum Düsseldorf Institut für Kardiologie, Pneumologie und AngiologieDüsseldorf, GermanyContact: Christian Jung, MDTaking people
- HELIOS Klinikum Erfurt, Medizinische Klinik III - KardiologieErfurt, GermanyContact: Alexander Lauten, MDTaking people
- Universitätsklinikum Erlangen, Medizinische Klinik 2Erlangen, GermanyContact: Stephan Achenbach, MDTaking people
- Elisabeth Krankenhaus Essen, Klinik für Kardiologie und AngiologieEssen, GermanyContact: Thomas Schmitz, MDTaking people
- Universitätsklinikum Essen, Klinik für Kardiologie und AngiologieEssen, GermanyContact: Tienush Rassaf, MDTaking people
- Universitätsklinikum Freiburg, Klinik für Kardiologie und AngiologieFreiburg im Breisgau, GermanyContact: Christoph Oliver, MDNot yet recruiting
- Klinikum Fulda, Medizinischen Klinik 1 - Kardiologie, Angiologie und IntensivmedizinFulda, GermanyContact: Volker Schächinger, MDTaking people
- Universitätsklinikum Gießen und Marburg GmbH, Medizinische Klinik I, KardiologieGiessen, GermanyContact: Samuel Sossalla, MDTaking people
- University Medical Center Göttingen, Department of Cardiology and Pneumology, Georg-August UniversityGöttingen, GermanyContact: Karl Toischer, MD, Prof.Not yet recruiting
- Universitätsmedizin Greifswald, Klinik und Poliklinik für Innere Medizin BGreifswald, GermanyContact: Marcus Dörr, MDNot yet recruiting
- Universitätsklinikum Halle (Saale), Klinik für Innere Medizin IIIHalle, GermanyContact: Daniel Sedding, MDTaking people
- Asklepios Klinik AltonaHamburg, GermanyContact: Felix Meincke, MDTaking people
- Asklepios Klinik St. Georg, Kardiologie und Internistische IntensivmedizinHamburg, GermanyContact: Eike Tigges, MDTaking people
- Universitäres Herz- und Gefäßzentrum UKE Hamburg GmbH, Klinik für KardiologieHamburg, GermanyContact: Peter Clemmensen, MDTaking people
- Klinik für Kardiologie, Angiologie und Pneumologie, Medizinische Klinik 3, Universitätsklinikum HeidelbergHeidelberg, GermanyContact: Haitham Abu Sharar, MDTaking people
- Universitätsklinikum des Saarlandes, Klinik für Innere Medizin IIHomburg, GermanyContact: Saarraangan Kulenthiran, MDNot yet recruiting
- Universitätsklinikum Jena, Klinik für Innere Medizin I, Kardiologie, Angiologie, Internistische IntensivmedizinJena, GermanyContact: Christian Schulze, MDTaking people
- Vincentius-Diakonissen-Kliniken gAG Medizinische Klinik III, Kardiologie, Intensivmedizin, AngiologieKarlsruhe, GermanyContact: Claudius Jacobshagen, MDTaking people
- Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Innere Medizin III mit den Schwerpunkten Kardiologie und internistische IntensivmedizinKiel, GermanyContact: Derk Frank, MDNot yet recruiting
- Asklepios Klinik Langen, Abteilung Medizinische Klinik ILangen, GermanyContact: Ralf Lehmann, MDTaking people
- Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/CardiologyLeipzig, GermanyContact: Holger Thiele, MD, Prof. Dr.Taking people
- Klinikum St. Georg gGmbH Klinik für Kardiologie und Internistische IntensivmedizinLeipzig, GermanyContact: Norbert Klein, MDNot yet recruiting
- Universitätsklinikum Leipzig, Klinik und Poliklinik für KardiologieLeipzig, GermanyContact: Christian Spies, MDTaking people
- Universitätsklinikum Schleswig Holstein, Medizinische Klinik II, Campus LübeckLübeck, GermanyContact: Ingo Eitel, MDNot yet recruiting
- Klinikum der Stadt Ludwigshafen, Medizinische B KlinikLudwigshafen, GermanyContact: Ralf Zahn, MDTaking people
- Universitätsklinikum Magdeburg, Klinik für Kardiologie und AngiologieMagdeburg, GermanyContact: Alexander Schmeisser, MDNot yet recruiting
- Brüderklinikum Julia Lanz, TheresienkrankenhausMannheim, GermanyContact: Ramon Tschierschke, MDNot yet recruiting
- Universitätsmedizin Mannheim, I. Medizinische Klinik, Kardiologie, Angiologie, Hämostaseologie und Internistische IntensivmedizinMannheim, GermanyContact: Ibrahim Akin, MDTaking people
- Universitätsklinikum Gießen und Marburg GmbH - Standort Marburg, Klinik für Innere Medizin - Kardiologie, Angiologie und IntensivmedizinMarburg, GermanyContact: Georgios Chatzis, MDNot yet recruiting
- Deutsches Herzzentrum München, Klinik für Herz- und KreislauferkrankungenMünchen, GermanyContact: Adnan Kastrati, MDTaking people
- Klinikum der Universität München, Medizinische Klinik und Poliklinik IMünchen, GermanyContact: Konstaninos Rizas, MDTaking people
- Klinikum NeumarktNeumarkt, GermanyContact: Ulrich Reiser, MDNot yet recruiting
- Klinikum Nürnberg, Medizinische Klinik 8 - Schwerpunkt Kardiologie, Universitätsklinik der Paracelsus Medizinischen PrivatuniversitätNuremberg, GermanyContact: Fadil Ademaj, MDTaking people
- Universitätsklinik für Kardiologie am Klinikum OldenburgOldenburg, GermanyContact: Albrecht Elsässer, MDTaking people
- Helios Vogtland-Klinikum PlauenPlauen, GermanyContact: Christian Bietau, MDNot yet recruiting
- Universitatsklinikum Regensburg, Klinik und Poliklinik fur Innere Medizin IIRegensburg, GermanyContact: Lars Maier, MDTaking people
- Universitätsmedizin Rostock, Zentrum für Innere Medizin, Abteilung für KardiologieRostock, GermanyContact: Alper Öner, MDTaking people
- Helios Kliniken Schwerin, Klinik für Kardiologie und AngiologieSchwerin, GermanyContact: Alexander Staudt, MDTaking people
- Krankenhaus der Barmherzigen Brüder Trier, Herzzentrum Innere Medizin III - KardiologieTrier, GermanyContact: Nikos Werner, MDTaking people
- Universitätsklinikum Tübingen, Medizinische Klinik, Innere Medizin III, Kardiologie und AngiologieTübingen, GermanyContact: Tobias Geisler, MDTaking people
- Schwarzwald-Baar Klinikum VS, Studienteam KardiologieVillingen-Schwenningen, GermanyContact: Sebastian Ewen, MDTaking people
- Städtisches Klinikum Wolfenbüttel gGmbH, Klinik für Innere Medizin - Kardiologie,Wolfenbüttel, GermanyContact: Björn Billmann, MDTaking people
- Helios Klinikum Wuppertal, HerzkreislaufforschungWuppertal, GermanyContact: Melchior Seyfarth, MDTaking people
About the trial
What the trial wants to find out
Prospective, randomized, controlled, multicenter, open-label trial to study whether multivessel percutaneous coronary intervention (PCI) is superior over culprit-lesion only PCI in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease.
The 2 groups in the trial
- culprit-lesion-only revascularizationTreatment being tested
Patients will receive optimal medical therapy without further revascularization of non-culprit lesions (neither during index hospitalization nor during follow-up). Angina pectoris will be treated medically as recommended in the chronic coronary syndrome guidelines. Revascularization of non-culprit lesions will only be permitted if at least one bailout criteria is met.
Treatment: Culprit-lesion revascularization
- multivessel complete revascularizationTreatment being tested
Patients will receive complete revascularization of all angiographically significant non-culprit lesions, either during the index procedure, the index hospitalization, or staged within 45 days after PCI of the culprit lesion.
Treatment: Culprit-lesion revascularization and Non-culprit-lesion revascularization
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI (-COMPLETE-NSTEMI-)
- Plain-language title
- Compares two stenting approaches in heart attack patients with multivessel coronary diseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 16 January 2025