Studying how eczema affects the brain, mood and thinking in teenagers
Follows teenagers with severe atopic eczema, looking at itch, sleep and mental health.
Plain-language title generated from the registry record
Registry title: Mind and Skin - the Neurocutaneous Axis in Atopic Eczema
Key facts
- Where
- London, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 18 years old?
Source: NCT05790330, who can take part
Where in United Kingdom
- Unit for Paediatric and Population-based Dermatology ResearchLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- King's College London
- Trial code
- NCT05790330
- Record updated
- 3 May 2024
- Original description
'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.Read full original descriptionShow less
'Mind and Skin': A Prospective Cohort Study Evaluating the Impact of Inflammation, Itch and Sleep Disturbance on the Brain, Mental Health and Cognition, in Patients With Severe Atopy
'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.
Inclusion: Patients aged 12 to 18 with atopic eczema (groups 1 and 2), which has been diagnosed by a Consultant Dermatologist; Patients with atopic eczema warranting systemic immuno-modulatory therapy or patients with atopic eczema on topical therapy or healthy controls; Written informed consent for study participation obtained from the patient or from the parent(s) / legal guardian, with assent as determined by the patient's age and level of understanding; Willingness to comply with all study requirements; Competent use of English language, according to patient's age (patients will be required to understand the written questionnaires and complying with instructions during MRI scanning).
Exclusion: Any clear contra-indication to MRI scanning. In particular this would be due to the presence of any implanted devices or metal from previous surgery or accident. This would be fully assessed with a standardised safety questionnaire by a radiographer prior to MRI scanning; Previous and/or current substance misuse; Patients who take medications that would, in the investigator's opinion, impact on quality of sleep studies; Any condition deemed by the Investigator to limit a patient's ability to undertake MRI components of the study, for example significant claustrophobia; Diagnosed by a sleep medicine specialist with a formal sleep disorder, requiring systemic medication; Sleep disturbance from co-morbid illness (including physical and/or mental/psychological illness) other than atopic eczema, deemed by the Investigator to significantly impact on sleep components of the study; Insufficient understanding of the study by the patient and/or parent/guardian.