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Studying how eczema affects the brain, mood and thinking in teenagers

Follows teenagers with severe atopic eczema, looking at itch, sleep and mental health.

Key facts

Who runs it
King's College London
Where
London, United KingdomSee the site
Trial code
Registry title
Mind and Skin - the Neurocutaneous Axis in Atopic Eczema
Status
Recruiting
People taking part
90 people, planned
Started
10 Mar 2023
Expected to end
1 Jun 2027
Type of study
Observational, 3 groups
Treatments tested
  • Methotrexate
  • Dupilumab
Record updated
3 May 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for young people aged 12 to 18 with atopic eczema, either needing stronger medicine or on skin treatment, and also healthy controls.

Age
12 to 18 years
Sex
All sexes can join.
Disease stage
Atopic eczema diagnosed by a skin specialist; either needing medicine that acts on the whole body, or treated with creams and ointments only.

Main reasons for not taking part

  • Cannot safely have an MRI scan, for example implanted devices or metal in the body
  • Significant fear of closed spaces that limits the MRI part of the study
  • A formal sleep disorder diagnosed by a sleep specialist that needs medicine
  • Poor sleep caused by another illness, physical or mental, that would affect the sleep part of the study
  • Past or current substance misuse

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Patients aged 12 to 18 with atopic eczema (groups 1 and 2), which has been diagnosed by a Consultant Dermatologist
  • Patients with atopic eczema warranting systemic immuno-modulatory therapy or patients with atopic eczema on topical therapy or healthy controls
  • Written informed consent for study participation obtained from the patient or from the parent(s) / legal guardian, with assent as determined by the patient's age and level of understanding
  • Willingness to comply with all study requirements
  • Competent use of English language, according to patient's age (patients will be required to understand the written questionnaires and complying with instructions during MRI scanning)

Who cannot take part

  • Any clear contra-indication to MRI scanning. In particular this would be due to the presence of any implanted devices or metal from previous surgery or accident. This would be fully assessed with a standardised safety questionnaire by a radiographer prior to MRI scanning
  • Previous and/or current substance misuse
  • Patients who take medications that would, in the investigator's opinion, impact on quality of sleep studies
  • Any condition deemed by the Investigator to limit a patient's ability to undertake MRI components of the study, for example significant claustrophobia
  • Diagnosed by a sleep medicine specialist with a formal sleep disorder, requiring systemic medication
  • Sleep disturbance from co-morbid illness (including physical and/or mental/psychological illness) other than atopic eczema, deemed by the Investigator to significantly impact on sleep components of the study
  • Insufficient understanding of the study by the patient and/or parent/guardian

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 12 and 18 years old?

Where in United Kingdom

  • Unit for Paediatric and Population-based Dermatology ResearchLondon, United KingdomContact: Carsten FlohrTaking people

About the trial

What the trial wants to find out

'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.

The 3 groups in the trial

  • Severe eczema

    Patients aged 12-18 who have been diagnosed with atopic eczema and require starting systemic therapy.

    Treatment: Methotrexate and Dupilumab

  • Less severe eczema

    Patients aged 12-18 who have been diagnosed with atopic eczema and require topical steroid therapy only.

  • Healthy controls

    Patients ages 12-18 who do not have atopic eczema.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
'Mind and Skin': A Prospective Cohort Study Evaluating the Impact of Inflammation, Itch and Sleep Disturbance on the Brain, Mental Health and Cognition, in Patients With Severe Atopy
Plain-language title
Studying how eczema affects the brain, mood and thinking in teenagersGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT05790330, who can take part
Record updated
3 May 2024