Urine Tests Instead of Some Cystoscopies for Bladder Cancer Follow-up
Tests urine tests in place of some scoping procedures for adults with early bladder cancer.
Plain-language title generated from the registry record
Registry title: Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
Key facts
- Where
- Bay Pines, Charleston, Cleveland, Dallas, Lebanon, St Louis, Tampa, West Haven, West Roxbury, and White River Junction, United StatesSee the 10 sites
- Phase
- Phase 2
Where in United States
- Bay Pines VA Healthcare SystemBay Pines, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesNo longer taking part
- University Hospitals Cleveland Medical Center*Cleveland, United StatesTaking people
- UT Southwestern Medical CenterDallas, United StatesTaking people
- Dartmouth Hitchcock Medical CenterLebanon, United StatesTaking people
- VA St. Louis Healthcare SystemSt Louis, United StatesTaking people
- James A. Haley Veterans HospitalTampa, United StatesNo longer taking part
- West Haven VA Medical CenterWest Haven, United StatesTaking people
- VA Boston Jamaica Plains CampusWest Roxbury, United StatesTaking people
- White River Junction Veterans Healthcare SystemWhite River Junction, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- White River Junction Veterans Affairs Medical Center
- Trial code
- NCT05796375
- Record updated
- 16 September 2026
- Original description
The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, complications, cancer recurrence or cancer progression when some cystoscopy procedures are replaced with urine testing.Read full original descriptionShow less
Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, complications, cancer recurrence or cancer progression when some cystoscopy procedures are replaced with urine testing.
Inclusion: Aged 18 years or older; History of low grade intermediate-risk non-muscle invasive bladder cancer, defined as most recent pathology report showing any of the following:; multifocal low grade non-invasive urothelial carcinoma of any size; solitary low grade non-invasive urothelial carcinoma greater than 3cm in size; recurrent low grade non-invasive urothelial carcinoma; Stated willingness to comply with all study procedures and availability for the duration of the study; No evidence for recurrence at cystoscopy ≤6 months after most recent tumor resection; Ability to consent in English or Spanish.
Exclusion: History of total cystectomy of the bladder; History of urinary diversion (e.g., neo-bladder, colon pouch, or ileal conduit); History of muscle-invasive bladder tumor; History of urothelial carcinoma of the ureter or renal pelvis status post endoscopic treatment or with evidence of recurrent upper tract disease (inclusion allowed if status post nephroureterectomy and recurrence free at time of inclusion); Anatomic constraints making cystoscopy impossible (e.g., history of urethrectomy, obliterated urethra secondary to stricture); Pregnancy or lactation; Inability to provide a voided urine sample.