Predicting brain overflow after neck artery opening using deep learning
Uses deep learning to predict brain blood-flow surges after carotid artery treatment in adults.
Plain-language title generated from the registry record
Registry title: Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning
Key facts
- Where
- Minsk, BelarusSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 30 to 80 with narrowed or blocked neck (carotid) arteries who are due to have a procedure to restore blood flow.
- Age
- 30 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Narrowing or blockage of the carotid arteries, with an indication for carotid revascularization.
Main reasons for not taking part
- Atrial fibrillation
- Heart failure with left ventricular ejection fraction less than 40%
- Chronic kidney disease with estimated glomerular filtration rate less than 45 mL/min/1.73 m²
- Implanted cardioverter-defibrillator or pacemaker
- No temporal acoustic window for transcranial Doppler ultrasonography
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 80 years old?
Source: NCT05800821, who can take part
Where in Belarus
- State Institution "Republican Scientific and Practical Center "Cardiology"Minsk, BelarusTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
- Trial code
- NCT05800821
- Record updated
- 25 November 2025
- Original description
Cerebral hyperperfusion syndrome (CHS) was initially described as a clinical complication following carotid endarterectomy (CEA), but it may occur after both CEA and carotid artery stenting. It is characterised by throbbing ipsilateral frontotemporal or periorbital headache, and sometimes diffuse headache, eye and facial pain, vomiting, confusion, macular oedema, visual disturbances, focal motor seizures with frequent secondary generalisation, focal neurological deficits, and intracerebral or subarachnoid haemorrhage.Read full original descriptionShow less
Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning
Cerebral hyperperfusion syndrome (CHS) was initially described as a clinical complication following carotid endarterectomy (CEA), but it may occur after both CEA and carotid artery stenting. It is characterised by throbbing ipsilateral frontotemporal or periorbital headache, and sometimes diffuse headache, eye and facial pain, vomiting, confusion, macular oedema, visual disturbances, focal motor seizures with frequent secondary generalisation, focal neurological deficits, and intracerebral or subarachnoid haemorrhage.
Knowledge of CHS among physicians remains limited. Most studies report an incidence of 1-3% after carotid endarterectomy. CHS is most common in patients with increases of more than 100% in cerebral perfusion compared with baseline after carotid revascularization, and is rare in patients with perfusion increases of less than 100% compared with baseline.
The pathophysiological mechanism of CHS is only partially understood. The chronic low-flow state induced by severe carotid disease results in compensatory dilation of cerebral vessels distal to the stenosis, as part of the normal autoregulatory response to maintain adequate cerebral blood flow (CBF). In this chronically dilated state, the vessels lose their ability to autoregulate vascular resistance in response to changes in blood pressure. Dysautoregulation has been shown to be proportional to the duration and severity of chronic hypoperfusion. After revascularization and reperfusion, impaired cerebral autoregulation may contribute to a cascade of intracranial microcirculatory changes, with an inability to respond adequately to the augmentation of CBF following carotid recanalization.
Although most patients present with mild symptoms and signs, progression to severe and life-threatening complications can occur if CHS is not recognised and treated promptly. Because CHS is diagnosed on the basis of several non-specific signs and symptoms, patients may be misdiagnosed as having one of the better-known causes of perioperative complications, such as thromboembolism.
Inclusion: Age between 30 and 80 years; Occlusive-stenotic lesion of the carotid arteries with indications for carotid revascularization.
Exclusion: Epilepsy; History of traumatic brain injury; Demyelinating diseases of the central nervous system; History of neuroinfection; Chronic kidney disease with estimated glomerular filtration rate less than 45 mL/min/1.73 m²; Chronic heart failure with left ventricular ejection fraction less than 40%; Systemic vasculitis; Cerebral vessel aneurysms; Arteriovenous malformation of the brain; Primary brain tumor (including metastatic lesions); Atrial fibrillation; Frequent supraventricular or ventricular extrasystoles; Presence of an implanted cardioverter-defibrillator or pacemaker; Presence of contraindications to the medical use of iodine-containing radiographic contrast agents; Patient's unwillingness to continue participating in the study; Absence of a temporal acoustic window for transcranial Doppler ultrasonography.