Imaging Brain Inflammation in Multiple Sclerosis and Related Demyelinating Diseases
Tests MRI and PET scans to measure brain inflammation in people with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: A Study of Imaging in Demyelinating Diseases
Key facts
- Where
- Rochester, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Mayo Clinic MinnesotaRochester, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT05805839
- Record updated
- 17 September 2026
- Original description
This purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS).Read full original descriptionShow less
Advanced MR and PET Imaging in Inflammatory Demyelinating Diseases of the Central Nervous System
This purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS).
Inclusion: Meet the requirements for one of the case or control groups; MS patients undergoing neurologic evaluation procedures as part of Understanding Sex Differences in Multiple Sclerosis Spectrum of Demyelinating Disorders (IRB# 19-002807) Study or the Mayo Clinic Neurology Multiple Sclerosis Clinic; Control participants without inflammatory-demyelinating diseases of the central nervous system; Capacity to sign consent.
Exclusion: For all patients and controls, any acute glucocorticoid (e.g., IV methylprednisolone or PO prednisolone) use within 2 weeks is an exclusion to limit medication interaction but preserve possible chronic systemic inflammation interaction with microglia activation metrics. Chronic disease modifying treatments in MS are allowed as these medications are not known to impact microglia activation; Participants unable to lie down without moving for 20 minutes; Women who are pregnant or cannot stop breast feeding for 24 hours; Standard safety exclusionary criteria for MRI such as metallic foreign bodies, pacemaker, etc., since the quantitative PET data analysis is based on anatomic criteria that are established uniquely for each subject by registration to his/her MRI.