The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
Key facts
- Where
- Montreal, CanadaSee the site
- Phase
- Phase 4
Where in Canada
- Centre Hospitalier Universitaire de Montréal - Hôtel-DieuMontreal, CanadaContact: Dien Hung Luong, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre hospitalier de l'Université de Montréal (CHUM)
- Trial code
- NCT05806021
- Record updated
- 5 February 2025
- Original description
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying degrees of pain. When pain is bothersome, osteoarthritis is treated to improve functional abilities.Read full original descriptionShow less
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis: a Non-inferiority Randomized Controlled Double-blind Study
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying degrees of pain. When pain is bothersome, osteoarthritis is treated to improve functional abilities.
One of the most recognized and used treatments is intra-articular cortisone injection. Cortisone is a powerful anti-inflammatory drug that is used to reduce pain.
Unfortunately, cortisone can have significant side effects, even when injected locally. The frequency and intensity of these side effects depend largely on the total dose injected. The main side effects include increased blood sugar levels, increased blood pressure and a temporary decrease in the secretion of the stress hormone, cortisol. In the long term, a decrease in articular cartilage thickness in the injected join and overall bone density reduction is also reported.
Despite many years of routine use, the smallest effective dose of cortisone injected into the knee joint is unknown.
The main objective of the study is to determine the impact on pain and function of different doses of cortisone injected into the knee. The cortisone chosen for this study is triamcinolone acetonide (TA).
Inclusion: Symptomatic primary gonarthrosis of over 6 months duration (gonarthrosis according to the American College of Rheumatology criteria); Grade 1 to 3 Kellgren-Lawrence femorotibial osteoarthritis; Knee pain provoked by activity over 4 and under 8 on 10 (Visual Analog Scale).
Exclusion: Intra-articular corticosteroid infiltration to the knee within the past 3 months or chronic use of per os corticosteroid; Disease affecting the study joint (systemic inflammatory disease, history of septic arthritis, osteonecrosis, etc.); Significant cognitive impairment or inadequate language proficiency not allowing adequate response to study questionnaires; Any other serious medical condition that does not allow participation in the study or may be a contraindication to cortisone injection; Intra-articular infiltration of platelet-rich plasma within the past 12 months; Bilateral symptomatic primary gonarthrosis; Grade 4 Kellgren-Lawrence femorotibial osteoarthritis; Isolated patellofemoral osteoarthritis; Intra-articular hyaluronic acid infiltration within the past 12 months; Suspicion or presence of active local infectious process; Presence or suspicion of local neoplasia or metastasis; Recent severe trauma to the knee (≤ 3 months).