Effects of Exercise Versus Topical Agents on Knee Osteoarthritis
Key facts
- Who runs it
- Istanbul University - Cerrahpasa
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 79 people enrolled
- Started
- 15 Apr 2024
- Ended
- 15 Jun 2025
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Exercise
- Exercise&Topical Agent
- Topical Agent
- Record updated
- 4 September 2025
Who can take part
- Age
- 40 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Diagnosed with knee OA according to the criteria of the American Society of Rheumatology
- Stage 2 or 3 according to Kellgren Lawrence radiological staging criteria
- Those between the ages of 40 and 65
- Body mass index below 30 kg/m2
- Pain intensity defined by the patient in the last 3 months is at least 3 out of 10 according to NPRS
- Patients who do not have any obstacles to be included in the exercise program
Who cannot take part
- Using viscosupplementation or steroid injection or systemic steroids in the related knee in the last 3 months
- To have received a physiotherapy program for the relevant knee in the last 3 months
- Presence of active infection or tumor
- Presence of neurological diseases and/or deformity leading to lower extremity muscle weakness
- Having serious systemic and cardiovascular diseases that interfere with exercise
- Having a valgus or varus deformity greater than 15°
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Osteoarthritis, a chronic and degenerative joint disease, is the most common type of arthritis and affects more than 300 million adults worldwide. Osteoarthritis, which is characterized by joint pain and stiffness, has negative consequences for function, participation and quality of life, which are important components of health. The knee joint is the most common joint in terms of osteoarthritis and is more common in individuals over 50 years of age.
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There is no proven definitive treatment in today's literature for common osteoarthritis, which is one of the important causes of the global disease burden. However, since it is a progressive disease with varying degrees of severity, it is a chronic problem that requires long-term treatment. According to current clinical guidelines prepared by the working groups of the International Osteoarthritis Research Society (OARSI) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases ESCEO , treatment typically includes physiotherapy interventions with the use of non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics, including intra-articular injections of corticosteroids; In more severe cases, joint replacement surgery is recommended.
The aim of this research project is to examine the effectiveness of a supervised exercise program applied in combination with NSAID-specific topical agents, in comparison with groups receiving only topical agents or only exercise treatments.
The 3 groups in the trial
- ExerciseExisting treatment, for comparison
Individuals with a diagnosis of knee osteoarthritis who underwent supervised exercise under the guidance of a physiotherapist for 6 weeks, 2 days a week.
- Exercise&Topical AgentExisting treatment, for comparison
Individuals with a diagnosis of knee osteoarthritis who had supervised exercise under the guidance of a physiotherapist for 6 weeks, 2 days a week, and in addition to this program, they used diclofenac gel 2 times a day, 4 days a week.
Treatment: Exercise, Exercise&Topical Agent, and Topical Agent
- Topical AgentExisting treatment, for comparison
Individuals with a diagnosis of knee osteoarthritis using diclofenac gel twice a day, 4 days a week, for 6 weeks
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Comparison of the Effectiveness of Exercise and Topical Agent Treatments in Knee Osteoarthritis: A Randomized Controlled Trial
- Record updated
- 4 September 2025