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Synolis VA 80/160 for hip osteoarthritis over 6 months

Tests Synolis VA 80/160 in adults with painful hip osteoarthritis.

Key facts

Who runs it
Aptissen SA
Where
France3 sites in 1 countryChoose a country to see its sites
Trial code
Registry title
6-month Efficacy and Safety of Synolis VA 80/160 in Hip Osteoarthritis
Status
Recruiting
People taking part
70 people, planned
Started
27 May 2024
Expected to end
Apr 2027
Type of study
Interventional
Treatments tested
  • SYNOLIS VA 80/160
Record updated
12 December 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with painful hip osteoarthritis (wear of the hip joint) who get one injection of Synolis VA 80/160 into the hip.

Age
Over 18 years.
Sex
All sexes.
Disease stage
Hip osteoarthritis at Kellgren-Lawrence X-ray stage II - III, with an X-ray taken no more than 6 months before the inclusion visit. Hip pain with an Oxford score ≥ 21/60. Symptoms for at least 2 months.
Earlier treatment
Pain medicines (analgesics and/or NSAIDs, or low-grade opioids) did not help enough or were not tolerated. No earlier visco supplement or corticosteroid injection in this hip, unless it was more than 6 months ago.

Main reasons for not taking part

  • Pregnancy.
  • Current or past infection of the affected joint, or a skin lesion near the injection site.
  • A hip replacement already planned.
  • Hip-conserving surgery, such as osteotomy or arthroscopy, less than 12 months ago.
  • Taking part in another clinical trial, or an illness that makes decision-making impossible.

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • Patient over 18 years of age,
  • Patient with osteoarthritis of the hip. The diagnosis is based on the following criteria:
  • Treated hip pain: Oxford score ≥ 21/60,
  • Kellgren-Lawrence positive X-ray stage: II - III (inclusion radiograph dated no more than 6 months before the inclusion visit),
  • Symptoms related to osteoarthritis of the hip for at least 2 months,
  • Failure of treatments (i.e., inadequate or ineffective response to analgesics and/or NSAIDs or intolerance to NSAIDs or low-grade opioids (leaving an OXFORD score ≥ 21/60),
  • Informed consent form signed by the patient,
  • The patient has never had a visco supplement injection or corticosteroid injection in the hip to be treated (or more than 6 months old)

Who cannot take part

  • The patient must not have undergone non-prosthetic hip-conserving surgery such as osteotomy or arthroscopy less than 12 months old
  • Recent or old infection of the affected joint,
  • Pregnancy,
  • Participation in another clinical trial,
  • Skin lesion near the injection site,
  • Patient with a programmed arthroplasty,
  • Patient with a pathology that makes decision-making impossible,

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Multicenter, independent study of Synolis VA 80/160 over a period of 6 months

The group in the trial

  • SYNOLIS VA 80/160Treatment being tested

    Single guided intra-articular injection of SYNOLIS VA 80/160

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
6-month Evaluation of the Efficacy and Safety of Synolis VA 80/160 in the Treatment of Symptomatic Hip Osteoarthritis
Plain-language title
Synolis VA 80/160 for hip osteoarthritis over 6 monthsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
12 December 2025