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Taking people in South KoreaNo phase

Compares two ways of guiding stent treatment in left main coronary artery disease

Compares fractional flow reserve-guided and angiography-guided stenting in adults with left main heart artery disease.

Plain-language title generated from the registry record
Registry title: Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease

Key facts

Where
Ansan, Anyang, Bucheon-si, Busan, Changwon, Chuncheon, Daegu, Daejeon, Gangneung, Gwangju, Gwangmyeong, Hwaseong-si, Ilsan, Incheon, Jeju City, Seongam, Seongnam, Seoul, Suwon, Ulsan, and Yŏngin, South KoreaSee the 42 sites

Where in South Korea

  • Korea University Ansan HospitalAnsan, South KoreaNo longer taking part
  • Hallym University Sacred Heart HospitalAnyang, South KoreaTaking people
  • Bucheon Sejong HospitalBucheon-si, South KoreaTaking people
  • Dong-A University HospitalBusan, South KoreaTaking people
  • Pusan National University HospitalBusan, South KoreaTaking people
  • Pusan National University Yangsan HospitalBusan, South KoreaNo longer taking part
  • Changwon Gyeongsang National University HospitalChangwon, South KoreaTaking people
  • Kangwon National University HospitalChuncheon, South KoreaTaking people
  • Daegu Catholic University Medical CenterDaegu, South KoreaTaking people
  • Keimyung University - Dongsan Medical CenterDaegu, South KoreaTaking people
  • Yeungnam University HospitalDaegu, South KoreaTaking people
  • Chungnam National University HospitalDaejeon, South KoreaTaking people
  • Daejeon St. Mary's Hospital, Catholic University of KoreaDaejeon, South KoreaTaking people
  • Gangneung Asan HospitalGangneung, South KoreaTaking people
  • Chonnam National University HospitalGwangju, South KoreaTaking people
  • Chung-Ang University Gwangmyeong HospitalGwangmyeong, South KoreaTaking people
  • Hallym University Dongtan Sacred Heart HospitalHwaseong-si, South KoreaTaking people
  • Inje University Ilsan Paik HospitalIlsan, South KoreaNot yet recruiting
  • National Health Insurance Service Ilsan HospitalIlsan, South KoreaTaking people
  • CHA Ilsan Medical CenterIlsan, South KoreaNo longer taking part
  • Ilsan Myongji HospitalIlsan, South KoreaNo longer taking part
  • Gachon University Gil Medical CenterIncheon, South KoreaTaking people
  • Inha University HospitalIncheon, South KoreaTaking people
  • Jeju National University HospitalJeju City, South KoreaNo longer taking part
  • Chungnam National University Sejong HospitalSeongam, South KoreaTaking people
  • Seoul National University Bundang HospitalSeongnam, South KoreaTaking people
  • Asan Medical CenterSeoul, South KoreaTaking people
  • Chung ang University HospitalSeoul, South KoreaTaking people
  • Eunpyeong St. Mary's Hospital, Catholic University of KoreaSeoul, South KoreaTaking people
  • Hanyang University HospitalSeoul, South KoreaTaking people
  • Kangbuk Samsung HospitalSeoul, South KoreaNot yet recruiting
  • Korea University Guro HospitalSeoul, South KoreaTaking people
  • Kyung Hee University HospitalSeoul, South KoreaTaking people
  • Seoul Metropolitan Boramae HospitalSeoul, South KoreaTaking people
  • Seoul National University HospitalSeoul, South KoreaTaking people
  • SoonChunHyang University Seoul HospitalSeoul, South KoreaTaking people
  • Yeouido St. Mary's Hospital, Catholic University of KoreaSeoul, South KoreaTaking people
  • Korea University Anam HospitalSeoul, South KoreaNo longer taking part
  • Ajou University HospitalSuwon, South KoreaTaking people
  • St. Vincent's Hospital, Catholic University of KoreaSuwon, South KoreaTaking people
  • Ulsan University HospitalUlsan, South KoreaTaking people
  • Yongin Severance HospitalYŏngin, South KoreaTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
Seung-Jung Park
Trial code
NCT05829889
Record updated
24 June 2026
Original description
The primary purpose of the study was to determine whether the 2-year probability of major adverse cardiac events (primary composite outcome) differed significantly between patients who underwent angiography-guided Percutaneous Coronary Intervention(PCI) and those who underwent Fractional Flow Reserve(FFR)-guided PCI in patients with Left Main Coronary Artery disease(LMCA).Read full original descriptionShow less

A Comparison of Fractional Flow Reserve- Versus Angiography-Guided Percutaneous Coronary Intervention in Patients With Left Main Coronary Artery Disease

The primary purpose of the study was to determine whether the 2-year probability of major adverse cardiac events (primary composite outcome) differed significantly between patients who underwent angiography-guided Percutaneous Coronary Intervention(PCI) and those who underwent Fractional Flow Reserve(FFR)-guided PCI in patients with Left Main Coronary Artery disease(LMCA).

Inclusion: The subject must be ≥20 years of age with angina and/or evidence of myocardial ischemia; Significant de novo LMCA disease, defined as ≥ 50% diameter stenosis by visual estimation with or without concomitant non-left main major epicardial coronary artery disease, amenable to PCI with drug-eluting stent(DES) implantation; The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethical Committee of the respective clinical site.

Exclusion: Recent ST Elevation Myocardial Infarction(<7 days prior to randomization); Contraindication or inability to take aspirin or P2Y12 inhibitors (clopidogrel, ticagrelor, or clopidogrel); Prior PCI of the left main trunk; Prior coronary artery bypass graft surgery; Concurrent medical condition with a limited life expectancy of less than 2 years; Participated in academic trials like strategic comparison studies conducted under standard therapy provided that there is no additional risk or a specific procedure to a subject and no interference between this trial and other studies; The presence of complex coronary disease anatomy or lesion characteristics or other cardiac condition(s) which leads the participating interventional cardiologist to believe that PCI is not suitable (i.e. the subject should be managed with coronary artery bypass graft or medical therapy alone); Requirement for other cardiac surgical procedure (e.g., valve replacement or aorta surgery); Subjects requiring or who may require additional surgery (cardiac or noncardiac) within 1 year; End-stage renal disease requiring renal replacement therapy; Subjects who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period. However, where at least one or more conditions are satisfied, it could be an exception according to an investigator's discretion; Severe left ventricular dysfunction (ejection fraction <30%); left anterior descending coronary artery (LAD) or left circumflex coronary artery (LCx) chronic total occlusion (CTO); Extremely calcified or tortuous vessels precluding FFR measurement; Cardiogenic shock and/or need for mechanical/pharmacologic hemodynamic support; Liver cirrhosis; Pregnant and/or lactating women; Participated in the observational study expected no effect on the safety and/or effectiveness evaluation of this trial; Screening failed before any interventional factor is involved.

ClinicalTrials.gov NCT05829889