Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS

Prior treatment

• Has an electronic implant of any kind (e.g. pacemaker)
• Has an electronic implant of any kind (e.g. pacemaker)

Other illness

• Has a history of active (clinically significant) skin disorders
• Has a history of allergic response to plastic materials
• Has a history of a neurological disease, including Central Nervous System disease (e.g., stroke, head injury, epilepsy) or Peripheral Nervous System disease (neuropathy, myopathy).
• Has a history of psychiatric disease (e.g., depression, bipolar disease) that is clinically diagnosed and/or with the current use of psychiatric medications (e.g., antidepressants) for an indication of a psychiatric disease.
• Has a history of active (clinically significant) skin disorders
• Has a history of allergic response to plastic materials

Other

• Is pregnant
• Has broken, damaged or irritated skin or rashes near the sensor application sites
• Is unstably housed or lack reliable contact information.
• Investigator judges that device retrieval will be difficult or unlikely
• Does not have a smartphone that will support the HG application
• Does not have daily access to a wireless connection
  • [HEALTHY CONTROLS]
• Is pregnant
• Has broken, damaged or irritated skin or rashes near the sensor application sites
• Is unstably housed or lack reliable contact information.
• Investigator judges that device retrieval will be difficult or unlikely
• Does not have a smartphone that will support the HG application
• Does not have daily access to a wireless connection

• Has ALS, classified as definite, probable, laboratory-supported probable, or possible ALS according to the revised El Escorial criteria or a related neurodegenerative disorder including ALS-FTD, PLS, PMA or asymptomatic individuals with a known ALS mutation (as previously confirmed during the individual's regular clinical care)
• Is the age of majority in their province of residence/treatment
• Has the cognitive capacity to provide informed consent
• Has proficiency in English or French in order to understand study instructions and respond to questionnaires
• Be between the ages of 40-80 unless age matched to a patient (+/-3 years) who is already enrolled.
• Is the age of majority in their province of residence/treatment
• Has the cognitive capacity to provide informed consent
• Has proficiency in English or French in order to understand study instructions and respond to questionnaires

Criteria the registry did not label

• [PATIENTS]