Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users
Key facts
- Who runs it
- Yale University
- Where
- New Haven, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 54 people enrolled
- Started
- 1 Jun 2023
- Ended
- 26 Feb 2025
- Type of study
- Interventional
- Treatments tested
- Intensive Day Monitoring
- Record updated
- 4 March 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Cannabis-using men and women who:
- have a past-year pattern of 1 or more cannabis use episodes per week
- do not meet criteria for any other substance use disorders other than mild Cannabis and Alcohol Use Disorder
- are at least 18 years old
- are fluent in English
- can provide negative alcohol breathalyzer and only positive for cannabis at all visits
- can provide written informed consent
Who cannot take part
- current use of medications that interfere with hypothalamic-pituitary-adrenal axis response
- current use of psychotropic drugs other than antidepressants
- meeting current or past for major psychiatric disorders, other than depression or anxiety disorder
- meeting criteria for a current Substance Use Disorder other than mild Cannabis Use Disorder and Alcohol Use Disorder
- any significant current medical conditions requiring medication, including neurological, renal, thyroid, cardiovascular, liver, endocrine, or immune conditions
- Individuals will be excluded if they:
- women who are pregnant, lactating, peri-/post-menopausal, or with hysterectomies
Where in United States
- Yale Stress CenterNew Haven, United States
About the trial
What the trial wants to find out
This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both cannabis cues and stressors.
The group in the trial
- Individuals who use cannabisTreatment being tested
Participants who are non-treatment seeking cannabis users (30 men, 30 women) ranging from once weekly use to multiple times daily. All participants will be recruited from the greater New Haven community and will complete four weeks of smartphone monitoring. During this monitoring period, they will also complete two three-consecutive days of intensive monitoring including more frequent smartphone surveys, saliva samples, heart rate monitoring, and an alcohol use monitor.
Treatment: Intensive Day Monitoring
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 4 March 2025