Imaging plaque in narrowed neck arteries to study stroke risk
Uses a PET-MR scan to study plaque in narrowed carotid arteries in adults without symptoms.
Plain-language title generated from the registry record
Registry title: CANF-Comb-II PET-MR in Atherosclerosis Multisite
Key facts
- Where
- Los Angeles and St Louis, United StatesSee the 2 sites
Where in United States
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Washington University in St. LouisSt Louis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Washington University School of Medicine
- Trial code
- NCT05838547
- Record updated
- 23 March 2026
- Original description
The goal of this observational study is to learn more about plaque biology in asymptomatic carotid artery stenosis (ACAS) patients through imaging. The main questions it aims to answer are:Read full original descriptionShow less
PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With Cu[64]-25%-CANF-Comb-II
The goal of this observational study is to learn more about plaque biology in asymptomatic carotid artery stenosis (ACAS) patients through imaging. The main questions it aims to answer are:
* To determine the ability of 64Cu-CANF-Comb positron emission tomography (PET) to risk stratify ACAS patients for stroke event, to include transient ischemic attack or remote ipsilateral intervention. * To further understand the role of Natriuretic Peptide Receptor C (NPRC) in the evolution of carotid atherosclerosis.
Participants will be asked to undergo a carotid PET-magnetic resonance imaging (MRI) examination to assess whether the carotid atherosclerosis uptake of 64Cu-CANF-Comb as measured by PET-MRI correlates with patient outcomes (stroke, transient ischemic attack, or remote ipsilateral intervention).
Inclusion: Adults, 18 years of age or older; Asymptomatic carotid artery stenosis patients who have undergone carotid Doppler/ultrasound imaging or other carotid imaging which have demonstrated a ≥ 60% diameter carotid artery stenosis; The treating surgeon has planned either treatment with optimal medical therapy (OMT) alone, or OMT and carotid endarterectomy (CEA) surgical intervention.
Exclusion: Prior history of CEA or carotid artery stent procedure on the ipsilateral side; Patients with an unstable clinical condition that in the opinion of the Sponsor-Investigator or designee precludes participation in the study; Past medical history of TIA or stroke within the last 6 months; Currently pregnant or lactating. All female subjects of childbearing potential must have a documented negative pregnancy test (serum or urine hCG) performed within 24 hours immediately prior to the administration of 64Cu-25%-CANF-Comb or documented post-menopausal defined as the cessation of menses for ≥ 12 months or documentation of having a bilateral oophorectomy and/or hysterectomy; Inability to receive and sign informed consent; Inability to tolerate up to 60 minutes in a supine position with arms down at sides for PET-MR imaging; Unwilling to comply with study procedures and/or unable to be available for the duration of the study outlined in the protocol; Contraindications to MR imaging (pacemaker, brain aneurysm clips, shrapnel, claustrophobia, etc.).