Heart blood flow during fast heartbeats in adults with heart disease
Measures heart blood flow and pressure during paced fast rhythms in adults with heart disease.
Key facts
- Who runs it
- Imperial College London
- Where
- London, United KingdomSee the site
- Trial code
- Registry title
- Coronary Flow During Rapid Heart Rates
- Status
- Recruiting
- People taking part
- 70 people, planned
- Started
- 1 Aug 2023
- Planned end
- 2 Jun 2026
- Type of study
- Observational, 4 groups
- Treatments tested
- Pressure and flow measurement during simulated VT
- Record updated
- 27 March 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who are already booked for a coronary angiogram or coronary angioplasty. It studies how the heart's blood flow behaves during fast heart rates.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- People referred for coronary angiography or coronary angioplasty, able to have pressure and flow measurements inside the heart arteries and a stent procedure if needed.
Main reasons for not taking part
- Cannot give valid consent
- Pregnant or breastfeeding women
- Unstable coronary artery disease (acute coronary syndrome)
- Severe multivessel coronary artery disease that can have bypass surgery
- Severe heart valve disease or severe (NYHA IV) heart failure
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Able to give valid consent
- Referred for coronary angiography or coronary angioplasty
- Suitable for percutaneous physiological interrogation and PCI when clinically indicated
Who cannot take part
- Unstable coronary artery disease (acute coronary syndrome)
- Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
- Severe heart valve disease
- Severe (NYHA IV) heart failure
- Unable to give valid consent
- Pregnant or breastfeeding women
Where in United Kingdom
- Imperial College NHS Foundation TrustLondon, United KingdomContact: Rahul BahlTaking people
About the trial
What the trial wants to find out
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are:
Read full original descriptionShow less
1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT?
Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.
The 4 groups in the trial
- Controls
10 patients with unobstructed coronary arteries, normal microvascular function and normal LV function.
Treatment: Pressure and flow measurement during simulated VT
- Coronary artery disease
25 patients with severe, single-vessel coronary artery disease of the proximal LAD or proximal other dominant vessel awaiting PCI.
Treatment: Pressure and flow measurement during simulated VT
- Microvascular dysfunction
15 patients with without severe disease in any coronary artery, impaired microvascular function and normal LV function.
Treatment: Pressure and flow measurement during simulated VT
- Heart failure
20 patients with LV systolic dysfunction (LVEF\<40%).
Treatment: Pressure and flow measurement during simulated VT
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability
- Plain-language title
- Heart blood flow during fast heartbeats in adults with heart diseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 27 March 2026