Low-Calorie Diet for Fatty Liver in Adults Born With Low Birth Weight
Tests a 4-week low-calorie diet in adults born small with fatty liver.
Plain-language title generated from the registry record
Registry title: Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
Key facts
- Where
- Aarhus and Herlev, DenmarkSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 35 and 40 years old?
Source: NCT05842850, who can take part
Where in Denmark
- steno diabetes center AarhusAarhus, DenmarkTaking people
- Steno Diabetes Center CopenhagenHerlev, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Steno Diabetes Center Copenhagen
- Trial code
- NCT05842850
- Record updated
- 4 May 2026
- Original description
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.Read full original descriptionShow less
Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.
Inclusion: subjects with NAFLD (liver fat content ≥5% liver fat content verified on MRS in the screening NAFLD study).
Exclusion: Family history of diabetes (siblings, parent, and grandparents); Disease/medication known to affect primary outcome; Metabolic/liver disease; BMI<18.5 and BMI>30 kg/m2; Self-reported high physical activity level; Alcohol intake above general recommendations; Weight gain/loss of >3 kg within the past 6 months.