Studies stress ulcer drugs given after clot removal in acute stroke patients
Observes whether stress ulcer drugs given to adults after stroke thrombectomy relate to outcomes.
Plain-language title generated from the registry record
Registry title: Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy
Key facts
- Where
- Baotou, Changsha, Dongguan, Fuzhou, Ganzhou, Guangzhou, Haikou, Hengyang, Heyuan, Hohhot, Huizhou, Wenzhou, and Yueyang, ChinaSee the 19 sites
Where in China
- Sinopharm North HospitalBaotou, ChinaTaking people
- The First Hospital of ChangshaChangsha, ChinaTaking people
- Dongguan Donghua HospitalDongguan, ChinaTaking people
- Dongguan People's HospitalDongguan, ChinaTaking people
- Fujian Medical University Union HospitalFuzhou, ChinaTaking people
- Ganzhou City People's HospitalGanzhou, ChinaTaking people
- Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou, ChinaTaking people
- Huadu District People's Hospital of GuangzhouGuangzhou, ChinaTaking people
- Nanfang Hospital of Southern Medical UniversityGuangzhou, ChinaTaking people
- The Fourth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, ChinaTaking people
- Haikou People's HospitalHaikou, ChinaTaking people
- Hainan Provincial People's HospitalHaikou, ChinaTaking people
- Hainan Traditional Chinese Medicine HospitalHaikou, ChinaTaking people
- The Second Hospital University of South ChinaHengyang, ChinaTaking people
- Heyuan People's HospitalHeyuan, ChinaTaking people
- The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot, ChinaTaking people
- Huizhou Municipal Central HospitalHuizhou, ChinaTaking people
- Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou, ChinaTaking people
- Yueyang People's HospitalYueyang, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Nanfang Hospital, Southern Medical University
- Trial code
- NCT05845372
- Record updated
- 5 November 2026
- Original description
Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel occlusive cerebral infarction, but 20-50% of patients still experience ineffective revascularization. Therefore, postoperative monitoring and treatment of patients with large vessel occlusions is crucial for early recognition, management and prevention of complications. Stress ulcer bleeding is a serious complication after acute ischemic stroke, with a prevalence of 1%-5%, and a previously proven incidence of stress ulcer bleeding after ischemic stroke. Stress ulcer bleeding after ischemic stroke has been shown to be closely associated with unfavorable outcomes, such as mortality. Current national and international guidelines or consensus on the prevention of stress ulcers after acute ischemic stroke do not advocate the routine use of histamine receptor antagonists or proton pump inhibitors for the prevention of stress ulcers, but rather should be considered in the context of the patient's risk factors for stress ulcers and discontinued after the patient initiates enteral nutrition. However, there is no evidence-based medical evidence to support the risk-benefit relationship of stress ulcer drug prophylaxis in patients with mechanical thrombectomy for acute anterior circulation large vessel occlusion.Read full original descriptionShow less
Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy: a Prospective, Multicenter, Observational Cohort Study
Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel occlusive cerebral infarction, but 20-50% of patients still experience ineffective revascularization. Therefore, postoperative monitoring and treatment of patients with large vessel occlusions is crucial for early recognition, management and prevention of complications. Stress ulcer bleeding is a serious complication after acute ischemic stroke, with a prevalence of 1%-5%, and a previously proven incidence of stress ulcer bleeding after ischemic stroke. Stress ulcer bleeding after ischemic stroke has been shown to be closely associated with unfavorable outcomes, such as mortality. Current national and international guidelines or consensus on the prevention of stress ulcers after acute ischemic stroke do not advocate the routine use of histamine receptor antagonists or proton pump inhibitors for the prevention of stress ulcers, but rather should be considered in the context of the patient's risk factors for stress ulcers and discontinued after the patient initiates enteral nutrition. However, there is no evidence-based medical evidence to support the risk-benefit relationship of stress ulcer drug prophylaxis in patients with mechanical thrombectomy for acute anterior circulation large vessel occlusion.
Inclusion: Age ≥18 years; Within 24 hours of onset. Meet the criteria for diagnosis of acute ischemic stroke in the "China Acute Ischemic Stroke Diagnosis and Treatment Guidelines 2018"; Meet the indications for mechanical thrombectomy in the "Chinese Guidelines for Early Endovascular Interventions in Acute Ischemic Stroke 2022"; Treated with mechanical thrombectomy; NIHSS score ≥ 6 at onset of illness; Sign an informed notice.
Exclusion: Allergy to drug ingredients. Women who are pregnant or breastfeeding. Life expectancy of less than 3 months due to other non-ischemic stroke diseases such as malignancy, severe liver or renal failure; Have participated in other interventional clinical studies (affecting the outcome of this cohort study); Participants who were judged by the investigator to be unsuitable for participation in this study.