Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study
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- Who runs it
- Heinrich-Heine University, Duesseldorf
- Trial code
- NCT05851209
- Record updated
- 30 June 2026
- Original description
Biomarkers and mechanisms in the progression of aortic valve stenosis are sometimes not sufficiently understood. The current project will take into account image morphological and immunological aspects that predict the development of hemodynamically relevant aortic valve stenosis in order to identify high-risk patients and to develop further therapeutic options.Read full original descriptionShow less
Evaluation of Immunologic and Image Morphologic Parameters to Predict Disease Progression in Patients With Moderate Aortic Valve Stenosis
Biomarkers and mechanisms in the progression of aortic valve stenosis are sometimes not sufficiently understood. The current project will take into account image morphological and immunological aspects that predict the development of hemodynamically relevant aortic valve stenosis in order to identify high-risk patients and to develop further therapeutic options.
Inclusion: The patient has an acquired (tricuspid) moderate aortic valve stenosis, which is the reason for regular outpatient cardiological care; The subject has been informed verbally and in writing about the study and has given written consent to participate in this study; Age > 18 years.
Exclusion: The subject has contraindications for the performance of a magnetic resonance imaging or computed tomography (e.g., severe arrhythmias , contrast agent intolerance, a pacemaker, or severe renal insufficiency or severe renal insufficiency or claustrophobia); Presence of only mild or already high-grade acquired tricuspid Aortic valve stenosis; Patient with bicuspid aortic valve; Inability to follow the instructions of study personnel; Lack of written informed consent.