Studies how social brain networks change in adults with autism
Tests PEERS, a behavioral social skills program, in adults with autism spectrum disorder.
Plain-language title generated from the registry record
Registry title: The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
Key facts
- Where
- Taipei, TaiwanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT05884853, who can take part
Where in Taiwan
- National Taiwan University HospitalTaipei, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT05884853
- Record updated
- 31 July 2026
- Original description
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.Read full original descriptionShow less
The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
Inclusion: age between 18 and 50; diagnosed with ASD from licensed mental health or medical professional based on DSM5; have social problems; motivated to participate in the treatment; fluent in chinese; caregiver also fluent in chinese and motivated to participate; had a full-scale IQ > 70 on WAIS-IV; scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD.
Exclusion: history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases; visual impairment and/or hearing impairment; any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.