NCT05896579Recruiting
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 31 May 2023
- Start date
- 22 Aug 2023
- Primary completion date
- May 2030
- Lead sponsor
- University of Colorado, Denver
- NCT number
- NCT05896579
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 22 Aug 2023 to the primary completion date, May 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Exacerbation of COPD in the 3 months prior to enrollment
- Change in COPD therapy in the 3 weeks prior to enrollment
Other illness
- Known pulmonary hypertension with mean pulmonary artery pressure \>45 mmHg
- Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
- Active malignancy (other than skin)
- Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.)
Lab values
- Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure \>150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)
Other
- Requirement of \>6 LPM supplemental oxygen at rest
- Requirement of \>10 LPM supplemental oxygen with exertion
- Volume overload (jugular vascular distension or greater than trace peripheral edema)
- World Health Organization Functional Class IV
- Pregnancy
- Body mass index \<18 or \>40
- Hematocrit \<25% or \>55%
- For invasive CPET, chronic anticoagulation that is unable to be held for the study visit
- For invasive CPET, forced expiratory volume in 1 second of \<20%
Who the study is looking for
- COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
- Age \>= 40 years
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colorado Anschutz Medical Campus Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.