Comparing outpatient and hospital evaluation for chest pain in the emergency department
Tests a quick outpatient check versus hospital stay for adults with chest pain.
Plain-language title generated from the registry record
Registry title: CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)
Key facts
- Where
- Charlotte, Detroit, and Winston-Salem, United StatesSee the 3 sites
Where in United States
- Carolinas Medical CenterCharlotte, United StatesTaking people
- Henry Ford HospitalDetroit, United StatesTaking people
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wake Forest University Health Sciences
- Trial code
- NCT05897632
- Record updated
- 30 September 2026
- Original description
The goal of this study is to determine if rapid outpatient evaluation vs hospitalization management is the best strategy (based on patient-centered measures and safe, equitable, and efficient resource use) for evaluating patients with acute chest pain who are at moderate risk for acute coronary syndrome (ACS). Patients will be randomized in the Emergency Department to either an outpatient evaluation (CARE-CP) or hospitalization evaluation for their symptoms.Read full original descriptionShow less
CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain )
The goal of this study is to determine if rapid outpatient evaluation vs hospitalization management is the best strategy (based on patient-centered measures and safe, equitable, and efficient resource use) for evaluating patients with acute chest pain who are at moderate risk for acute coronary syndrome (ACS). Patients will be randomized in the Emergency Department to either an outpatient evaluation (CARE-CP) or hospitalization evaluation for their symptoms.
Inclusion: Age ≥21 years old; Chest pain or Symptoms of acute coronary syndrome (ACS); Moderate risk of ACS (all of the below); Hear Score 4-6; Non-Ischemic electrocardiogram (ECG); Two Troponin measures < Sex-Specific Upper Reference Limit; Women <15 pg/ml; Men <20 pg/ml; No prior coronary artery disease (CAD); No Prior Myocardial Infarction (MI); No Prior Coronary Revascularization Procedures; No Patients with ≥ 70% Obstructive Coronary Disease.
Exclusion: Prior Enrollment; ST Elevation Myocardial Infarction (STEMI) Activation; Stress Echocardiography, Nuclear Stress Test, Stress ECG, Stress Cardiac MRI, Coronary CT Angiogram (CCTA), Invasive Coronary Angiography (Cardiac Cath) within 1 year; "Clean" CCTA or Cardiac Cath (0% stenosis in all vessels) within the past 2 years; Other comorbid conditions requiring hospitalization; Unstable Vitals (Blood Pressure <90, Heart Rate >120 or <50, O2 Sat <90%); End Stage Renal Disease; Dialysis or estimated glomerular filtration rate (eGFR) <30 mL/min; ST Changes or new T-wave inversions ≥1mm on ECG; Any Elevated Troponin Measure (Based on Sex-Specific 99th Percentile); Serial change between Troponin Measures (Delta) ≥5 pg/mL; Chest Trauma; Pregnancy; Life Expectancy < 1 year; Transfers From Another Hospital; Non-English Speaking; Prisoners; Already Enrolled in Other Interventional Trial.