Comparing two artery entry routes for clot removal in basilar artery stroke
Tests radial or femoral artery access for clot removal in adults with stroke.
Plain-language title generated from the registry record
Registry title: Radial Versus Femoral Access For Thrombectomy in Patients With Acute Basilar Artery Occlusion
Key facts
- Where
- Nanjing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a sudden stroke caused by a blocked basilar artery in the back of the brain. It compares clot removal through the wrist artery with the groin artery.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Acute stroke in the back part of the brain with a blocked basilar artery confirmed by CTA, MRA or DSA. Within 24 hours of the estimated time of the blockage. NIHSS score of 10 or more before randomization.
- Earlier treatment
- No stroke within 48 hours after a coronary or brain artery procedure or major surgery.
- Biomarker or test result
- Intact dual circulation of the hand on the modified Allen's test.
Main reasons for not taking part
- Disability before the stroke (mRS score 3 or more)
- Pregnant or breastfeeding women
- Allergy to contrast agents or nitinol devices
- Bleeding disorder, or high blood pressure that medicines cannot control
- Life expectancy less than 1 year
Read by machine on 9 November 2026.
Where in China
- Department of Neurology, Jinling HospitalNanjing, ChinaContact: Xinfeng Liu, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Jinling Hospital, China
- Trial code
- NCT05903560
- Record updated
- 30 April 2026
- Original description
Stroke is one of the most important diseases endangering the health and quality of life of Chinese people. Acute ischemic stroke (AIS) is commonly caused by cerebrovascular stenosis or occlusion. The most effective treatment for AIS is timely and successful angiographic reperfusion.Read full original descriptionShow less
Radial Versus Femoral Access For Thrombectomy in Patients With Acute Basilar Artery Occlusion
Stroke is one of the most important diseases endangering the health and quality of life of Chinese people. Acute ischemic stroke (AIS) is commonly caused by cerebrovascular stenosis or occlusion. The most effective treatment for AIS is timely and successful angiographic reperfusion.
Due to the large diameter and obvious positioning of bilateral femoral arteries, the transfemoral artery (TFA) using Seldinger's technique has been the most commonly used approach for endovascular treatment. However, recent studies have suggested that the radial artery is an ideal puncture site for cerebrovascular intervention. Small sample studies have confirmed that endovascular recanalization for acute anterior circulation large vessel occlusion via TRA has been safe and effective. Still, there are some complex approaches needed to be converted to TFA. There has been no difference in total operation duration and fluoroscopy time between TRA and TFA, but the TRA group had higher radiation dose and shorter hospital stays than the TFA group. In addition, TRA tends to be more convenient than TFA, especially for posterior circulation lesions.
However, the current studies are based on a single center with a small sample size, and there has been still a lack of large-sample randomized controlled experiments to verify the safety and effectiveness of posterior endovascular recanalization via TRA.
Inclusion: Acute ischemic stroke in the posterior circulation confirmed by symptoms and imaging examinations; Basilar artery occlusion confirmed by computed tomographic angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA); Age ≥ 18 years; Time from symptom onset to randomization within 24 hours of the estimated time of basilar artery occlusion; Baseline NIHSS score ≥ 10 before randomization; Intact dual circulation of the hand assessed by the modified Allen's test; Written informed consent from patients or their legally authorized representatives.
Exclusion: Systolic blood pressure > 185 mmHg or diastolic blood pressure > 110mmHg, and can not be controlled by antihypertensive drugs; Diseases or anatomical abnormalities that make it difficult for radial or femoral artery puncture, sheath insertion or instrument delivery, such as local infection, anatomical abnormalities confirmed by ultrasound or other imaging examinations, previous interventional or open surgery; Pre-stroke disability with mRS score ≥ 3; Allergic to contrast agents or nitinol devices; Acute ischemic stroke within 48 hours after percutaneous coronary intervention, cerebrovascular intervention, or major surgery (patients can be included if more than 48 hours); Premorbid nervous system diseases or mental disorders hindering the assessment of the disease; Known genetic or acquired bleeding diathesis, lack of coagulation factors; or oral anticoagulant therapy with INR > 1.7; Baseline lab values: blood glucose < 50mg/dL (2.8mmol/L) or > 400mg/dL (22.2 mmol/L), platelet count < 50*109 /L, or hematocrit < 25%; Pregnant or lactating women; Participation in other clinical trials; Life expectancy less than 1 year; Lost to follow-up within 90 days (e.g. no fixed residence, overseas patients, etc.); Clinical manifestations of central nervous system vasculitis.