Imaging study of brain scans in people with stroke from narrowed brain arteries
Uses MRI brain scans to study people with stroke from narrowed brain arteries.
Plain-language title generated from the registry record
Registry title: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Key facts
- Where
- Akron, Aurora, Birmingham, Buffalo, Carbondale, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Durham, Galveston, Hartford, Houston, Jacksonville, Lubbock, Manhasset, Miami, Minneapolis, New Haven, New York, Port Saint Lucie, St Louis, Toledo, Washington D.C., and Wyoming, United StatesSee the 28 sites
Where in United States
- Cleveland Clinic Akron GeneralAkron, United StatesNot yet recruiting
- University of Colorado HospitalAurora, United StatesNot yet recruiting
- University of Alabama HospitalBirmingham, United StatesTaking people
- Buffalo General Medical CenterBuffalo, United StatesTaking people
- SIH Memorial Hospital of CarbondaleCarbondale, United StatesNot yet recruiting
- Carolinas Medical CenterCharlotte, United StatesNot yet recruiting
- UVA Medical CenterCharlottesville, United StatesTaking people
- University of Chicago Medical CenterChicago, United StatesTaking people
- University of Illinois HospitalChicago, United StatesTaking people
- University of Cincinnati Medical CenterCincinnati, United StatesTaking people
- UH Cleveland Medical CenterCleveland, United StatesTaking people
- Prisma Health Richland HospitalColumbia, United StatesNot yet recruiting
- Duke University HospitalDurham, United StatesNot yet recruiting
- University of Texas Medical BranchGalveston, United StatesTaking people
- Hartford HospitalHartford, United StatesNot yet recruiting
- Memorial Hermann Texas Medical CenterHouston, United StatesNot yet recruiting
- Baptist Medical Center JacksonvilleJacksonville, United StatesTaking people
- Covenant Medical CenterLubbock, United StatesNot yet recruiting
- North Shore University HospitaManhasset, United StatesTaking people
- Jackson Memorial Hospital, MiamiMiami, United StatesTaking people
- M Health Fairview University of Minnesota Medical CenterMinneapolis, United StatesNot yet recruiting
- Yale New Haven HospitalNew Haven, United StatesTaking people
- NYP Columbia University Medical CenterNew York, United StatesNot yet recruiting
- Cleveland Clinic Tradition HospitalPort Saint Lucie, United StatesNot yet recruiting
- Barnes-Jewish HospitalSt Louis, United StatesTaking people
- Mercy St. Vincent Medical CenterToledo, United StatesNot yet recruiting
- MedStar Washington Hospital CenterWashington D.C., United StatesTaking people
- Metro Health HospitalWyoming, United StatesNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Yale University
- Trial code
- NCT05907629
- Record updated
- 16 July 2026
- Original description
CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial [a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.Read full original descriptionShow less
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial [a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.
Inclusion: Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA; Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen.
Exclusion: Gadolinium contrast allergy or acute or chronic kidney disease with eGFR<30 ml/min/1.73m2; Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62.