Comparing endovascular stroke treatment with medical care in disabled stroke patients
Compares clot-removal procedure with standard medical care in adults with ischemic stroke and prior disability.
Plain-language title generated from the registry record
Registry title: Treatment With Endovascular Intervention for STroke Patients With Existing Disability
Key facts
- Where
- Atlanta, Austin, Birmingham, Boston, Brooklyn, Charlottesville, Chicago, Cincinnati, Cleveland, Columbus, Englewood, Hartford, Houston, Los Angeles, Louisville, Memphis, Miami, Morgantown, Nashville, New Haven, New York, Palo Alto, Phoenix, Pittsburgh, Portland, Saint Loius, Salt Lake City, San Diego, Seattle, and Tulsa, United StatesSee the 35 sites
Where in United States
- Emory UniversityAtlanta, United StatesTaking people
- University of Texas at AustinAustin, United StatesTaking people
- University of Alabama at BirminghamBirmingham, United StatesTaking people
- Boston Medical CenterBoston, United StatesTaking people
- New York UniversityBrooklyn, United StatesTaking people
- University of VirginiaCharlottesville, United StatesTaking people
- University of ChicagoChicago, United StatesTaking people
- TriHealth Good Samaritan HospitalCincinnati, United StatesTaking people
- University of Cincinnati Medical CenterCincinnati, United StatesTaking people
- Cleveland ClinicCleveland, United StatesTaking people
- The Ohio State University -Wexner Medical CenterColumbus, United StatesTaking people
- Swedish Medical CenterEnglewood, United StatesNo longer taking part
- Hartford Health HospitalHartford, United StatesTaking people
- Houston Methodist Neurological InstituteHouston, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesTaking people
- University of California at Los AngelesLos Angeles, United StatesTaking people
- University of LouisvilleLouisville, United StatesTaking people
- Baptist Memorial HospitalMemphis, United StatesTaking people
- Baptist Hospital of MiamiMiami, United StatesTaking people
- University of MiamiMiami, United StatesTaking people
- West Virginia UniversityMorgantown, United StatesNo longer taking part
- Vanderbilt University Medical CenterNashville, United StatesTaking people
- Yale UniversityNew Haven, United StatesTaking people
- Columbia UniversityNew York, United StatesTaking people
- Icahn School of Medicine at Mount SinaiNew York, United StatesTaking people
- Stanford UniversityPalo Alto, United StatesTaking people
- HonorHealthPhoenix, United StatesTaking people
- University of Pittsburgh Medical CenterPittsburgh, United StatesTaking people
- Providence St. Vincent Medical CenterPortland, United StatesTaking people
- Barnes Jewish HospitalSaint Loius, United StatesTaking people
- University of UtahSalt Lake City, United StatesTaking people
- University of California San DiegoSan Diego, United StatesTaking people
- University of WashingtonSeattle, United StatesTaking people
- Ascension St. JohnTulsa, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Cincinnati
- Trial code
- NCT05911568
- Record updated
- 2 September 2026
- Original description
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.Read full original descriptionShow less
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.
Inclusion: Adult patients (≥18 years); Moderate-to-severe pre-stroke functional disability, defined as mRS 3-4, for at least 3 months prior to stroke onset; Presenting to study hospital within 24 hours of last known well time; Diagnosis of acute ischemic stroke; Intracranial causative occlusion of the internal carotid artery or the M1 or dominant M2 segments of the middle cerebral artery visualized on the baseline CT(or MR) angiogram; Presenting CT Alberta Stroke Program Early CT (ASPECT) score ≥3 or MRI ASPECT score ≥4; Presenting NIH Stroke Scale score ≥6; Informed consent from patient if competent or from legally authorized representative.
Exclusion: Known diagnosis of a terminal cancer or terminal illness at the time of stroke; Assessment of pre-stroke functional status cannot be performed during the hospital stay; Pre-stroke disability deemed temporary in the investigator's opinion (for example, recovering from a general medical illness or traumatic bodily injury).