Saline infusion and thinking skills in long COVID and POTS
Tests whether a saline drip affects thinking in adults with long COVID or POTS.
Plain-language title generated from the registry record
Registry title: NC Testing in LC & POTS
Key facts
- Where
- Calgary, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Long COVID or POTS who have brain fog, and also healthy people without POTS or brain fog.
- Age
- 18 to 60 years
- Sex
- Women and men
- Disease stage
- Long COVID: positive SARS-COV2 test and symptoms more than 12 weeks after COVID. POTS: diagnosis from the Calgary Autonomic Investigation and Management Clinic.
- Biomarker or test result
- Positive SARS-COV2 test for people with Long COVID.
Main reasons for not taking part
- Obvious causes of POTS, such as dehydration or prolonged bed rest
- Cannot safely stop medicines that could make test results hard to read
- Other factors that the investigator thinks would stop you from finishing the trial
- Cannot give informed consent
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT05914649, who can take part
Where in Canada
- University Of CalgaryCalgary, CanadaContact: Satish R Raj, MD, MSCITaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Calgary
- Trial code
- NCT05914649
- Record updated
- 7 May 2026
- Original description
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).Read full original descriptionShow less
Neurocognitive Testing in Long COVID and Postural Tachycardia Syndrome Patients With Normal Saline: A Pilot Study
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
Inclusion: Patients with diagnosis of Long COVID; SARS-COV2 test positive; Symptoms > 12 weeks post COVID; Subjective complaint of 'brain fog" or cognitive dysfunction; Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic; Subjective complaint of 'brain fog" or cognitive impairment; Healthy participants; Without POTS or "brain fog"; Age 18 to 60 years; Female and Male; Able to give an informed consent.
Exclusion: Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule; Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest); An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible; Unable to give an informed consent.