Diuretic Use in Hemodialysis Patients With Residual Renal Function

Who can take part

• Adult patients (age 18 years or older), who are within their first 12 months of chronic (expected to need dialysis for at least 6 months), in-centre hemodialysis therapy, and
• Residual renal function defined as 24-hour urine volume >200cc, and
• Life expectancy of at least 6 months, and
• Participants must be able to understand the consent process and be able to sign a consent form or have a substitute decision maker who is able to understand and sign consent on their behalf. In the case of non-English speaking participants, a translator service will be used to provide study information and obtain consent

Who cannot take part

• Unable to take oral medications
• Patients expecting to change modality (peritoneal dialysis, home dialysis) or to receive a renal transplant in the next 6 weeks
• Use of loop, or thiazide diuretic medications in the last week (if a patient is on chronic diuretics, they would need to be discontinued for 1 week before starting the trial)
• Documented allergy or adverse reaction to furosemide or chlorthalidone
• History of hypokalemia (<3.0 mmol/L), hypomagnesemia (<0.6mmol/L), or hypocalcaemia (<1.9mmol/L) in preceding 2 weeks
• Unable to complete baseline urine collection
• Already participating in another study and one of the studies could interfere with the other study