Frontlight ResearchEarly access
Taking people in United StatesEarly phase 1
Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
Key facts
- Who runs it
- Anna Stanhewicz, PhD
- Where
- Iowa City, United StatesSee the site
- Trial code
- Status
- Recruiting
- Phase
- Early phase 1
- People taking part
- 30 people, planned
- Started
- 11 Sept 2024
- Expected to end
- 30 Jun 2028
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Metformin Hydrochloride
- placebo
- Record updated
- 28 October 2026
Who can take part
- Age
- 18 years to 45 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- ≥12 weeks and ≤5 years postpartum
- history of GDM or healthy pregnancy
Who cannot take part
- cardiovascular or metabolic medication
- cardiovascular or metabolic disease
- history of hypertension during pregnancy
- prediabetes or diabetes (HbA1c ≥5.7%)
- current tobacco use
- current pregnancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Where in United States
- University of IowaIowa City, United StatesContact: Anna Stanhewicz, PhDTaking people
About the trial
What the trial wants to find out
The purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in these women before the onset of disease.
The 2 groups in the trial
- metforminExisting treatment, for comparison
Treatment: Metformin Hydrochloride
- placeboPlacebo, for comparison
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT05917587, who can take part
- Record updated
- 28 October 2026