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Taking people in United StatesNo phase

Effects of rTMS on Food Choice in Anorexia Nervosa

Key facts

Who runs it
New York State Psychiatric Institute
Where
New York, United StatesSee the site
Trial code
Status
Recruiting
People taking part
72 people, planned
Started
24 Apr 2023
Expected to end
30 Jun 2027
Type of study
Interventional, 2 groupsOne group gets a sham (pretend) treatment, for comparison.
Treatments tested
  • High-frequency repetitive transcranial magnetic stimulation (active rTMS)
  • Sham repetitive transcranial magnetic stimulation (sham rTMS)
Record updated
15 July 2026

Who can take part

Age
18 years to 35 years
Sex
Women only
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 22 criteriaShow less

Who can take part

  • DSM-5 Diagnosis of Anorexia Nervosa
  • Age 18-35 years
  • Female
  • Right-handed
  • Body Mass Index (BMI) ≥ 16.0
  • Voluntarily admitted to inpatient eating disorders unit at NYSPI
  • Competent to provide informed consent
  • English-speaking
  • Medically stable

Who cannot take part

  • Prior exposure to TMS
  • Hearing loss (e.g., currently undergoing treatment with ototoxic medications or those with cochlear implants)
  • Current substance use disorder or other co- morbid psychiatric condition requiring specialized treatment (e.g., psychosis)
  • Diagnosis of major medical or neurological problem or taking medication that significantly increases risk for seizure or affects interpretation of findings (e.g., unstable hypertension, seizure disorder)
  • Food restrictions (e.g., allergies) which impact greater than 30% of food choice task's choice options
  • History of seizure
  • Diagnosis of epilepsy, stroke, multiple sclerosis, traumatic brain injury, Alzheimer's and other neurodegenerative diseases, meningoencephalitis or intracerebral abscess, or parenchymal or leptomeningeal cancers
  • High risk of suicide
  • Indwelling ferromagnetic metallic object (e.g., pacemaker, pump), non- removable metal jewelry, medicinal patch or recent metallic ink tattoo
  • Pregnancy
  • Currently breast-feeding
  • Significant claustrophobia
  • Implanted devices or stimulators

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 35 years old?

Where in United States

  • New York State Psychiatric InstituteNew York, United StatesContact: Alexandra F Muratore, PhDTaking people

About the trial

What the trial wants to find out

This study will examine the impact of high-frequency repetitive transcranial magnetic stimulation on food choice behavior and related neural activity.

The 2 groups in the trial

  • High-frequency repetitive transcranial magnetic stimulation (HF-rTMS)Treatment being tested

    Target: Region of right DLPFC with greatest resting-state functional connectivity to dorsal striatum (individualized functional target) Protocol: 10 pulses/sec, 4s trains, 120% MT, 3000 pulses/session

    Treatment: High-frequency repetitive transcranial magnetic stimulation (active rTMS)

  • Sham repetitive transcranial magnetic stimulation (sham rTMS)Sham treatment, for comparison

    Target: Region of right DLPFC with greatest resting-state functional connectivity to dorsal striatum (individualized functional target) Protocol: same as HF-rTMS, with sham coil

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Deciphering the Neural Mechanisms of Restrictive Eating in Anorexia Nervosa Using Repetitive Transcranial Magnetic Stimulation
Fit questions
Built from NCT05918835, who can take part
Record updated
15 July 2026