Obstructive Sleep Apnea - Autonomic and Vascular Exploration
Key facts
- Who runs it
- Raphael Heinzer
- Where
- Switzerland1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 65 people enrolled
- Started
- 12 Jan 2024
- Ended
- 11 Sept 2024
- Type of study
- Interventional
- Treatments tested
- CPAP withdrawal
- Record updated
- 12 December 2025
- Why it stopped
- Difficulty recruiting desired number of participant.
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Age ≥18 years old
- Diagnosed with OSA (AHI ≥15 events/h), confirmed during screening period
- Adequately treated with CPAP therapy for ≥6 months
- Able to give informed consent as documented by signature
Who cannot take part
- We will also exclude patients with conditions that may affect endothelial and autonomic function:; Known Diabetes; Known heart failure; Known chronic kidney disease; Pregnant or lactating women; Morbid obesity (≥40 kg/m2); Known Excessive alcohol consumption; Known Dementia (especially dementia with Lewy bodies). (61); Patients using alpha and beta blockers; Known atrial fibrillation; Inability to follow the procedures of the study due to language problems or psychological disorders
- Professional drivers will be excluded from the study because temporary withdrawal of CPAP may induce drowsiness
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this clinical trial is to assess the effect of CPAP withdrawal on vascular and autonomic function in patients with obstructive sleep apnea. The main question it aims to answer is:
Read full original descriptionShow less
• Is the pulse wave amplitude index able to predict the impact of sleep apnea treatment withdrawal (continuous positive airway pressure, CPAP) on endothelial function and baroreflex sensitivity?
Participants will stop using their CPAP for 2 weeks and the investigators will assess vascular and autonomic function before and after the withdrawal. Researchers will compare endothelial and autonomic function at baseline and after 2 weeks of withdrawal to see if there are differences. Moreover, they will assess the association between pulse wave amplitude drop profile and effect of CPAP withdrawal.
The group in the trial
- CPAP withdrawalTreatment being tested
CPAP withdrawal for 2 weeks
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Noctural Pulse Waves Variations in OSA as a Predictor of Autonomic and Vascular Response to CPAP Therapy
- Record updated
- 12 December 2025