Studies heart valve leakage in people with atrial fibrillation
Observes heart valve leakage and outcomes in adults with irregular heartbeat.
Plain-language title generated from the registry record
Registry title: Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- St. Bartholomew's HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Barts & The London NHS Trust
- Trial code
- NCT05920824
- Record updated
- 16 July 2026
- Original description
A prospective, observational cohort study designed to identify clinical phenotypes and evaluate predictors \& outcomes of functional mitral and tricuspid valve regurgitation in patients with atrial fibrillation.Read full original descriptionShow less
Clinical Phenotypes, Risk Factors, & Determinants of Outcome in Functional Mitral and Tricuspid Valve Regurgitation
A prospective, observational cohort study designed to identify clinical phenotypes and evaluate predictors \& outcomes of functional mitral and tricuspid valve regurgitation in patients with atrial fibrillation.
Participant will under go:
* Baseline echocardiography * Cpex Echocardiography * Blood test: BNP * 1 year follow up Echocardiography
Participants will be stratified into three subgroups:
* Atrial Functional MR * Atrial Functional TR * Mixed MR \& TR
Inclusion: Informed consent; Age of 18 years or older; Atrial fibrillation; Moderate or severe atrial valve disease; Adequate 2D echocardiography views including parasternal long axis, short axis, apical two chamber, apical three chamber and four chamber.
Exclusion: Primary/organic valve disease; Left ventricular impairment (ejection fraction < 50%); Unwilling or unable to give consent.