The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Heat Stroke
Key facts
- Who runs it
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Where
- China7 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 104 people enrolled
- Started
- 28 May 2023
- Ended
- 1 Jun 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Normal Saline infusion and Ringer lactate infusion
- Record updated
- 4 June 2026
- Why it stopped
- Terminated due to protocol amendment: intervention window changed from entire ED stay to first 2h after ED admission. Revised protocol will be registered separately.
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- ≥ 18 years
- diagnosed as heat stroke
- Informed consent from patients or family members
Who cannot take part
- with original end-stage renal disease or dialysis
- need immediate cardiopulmonary resuscitation
- transferred from another hospital
- with severe organ damage
- pregnant women
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. The main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.
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Participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate Ringer's instead.
Researchers will compare the normal saline infusion group and sodium lactate Ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.
The 2 groups in the trial
- Normal Saline infusion groupExisting treatment, for comparison
During the emergency department, the normal saline infusion was not restricted.
Treatment: Normal Saline infusion and Ringer lactate infusion
- Ringer lactate infusion groupTreatment being tested
Use ringer lactate or other balanced crystallographic solution instead of normal saline. Strictly limit the amount of normal saline infusion. Normal saline will only be infused by medical advice if the patient has hypochloremia or needs saline as solvent.
Treatment: Normal Saline infusion and Ringer lactate infusion
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Patients With Heat Stroke
- Record updated
- 4 June 2026