3-point vs 6-point GNRFA for Chronic KOA
Key facts
- Who runs it
- McMaster University
- Where
- Canada1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Withdrawn
- Started
- 9 Aug 2025
- Ended
- 1 Apr 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Radiofrequency ablation
- Record updated
- 4 June 2026
- Why it stopped
- Unable to secure funding.
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Age 18 years or older
- Chronic knee pain for at least 3 months with radiological evidence of KOA graded 2-4 on the Kellgren-Lawrence scale as determined by a radiologist
Who cannot take part
- prior knee surgery,
- chronic opioid consumption of daily morphine equivalent of >30 mg for at least four weeks prior to procedure,
- neurologic diseases affecting the lower limbs (i.e. previous CVA, MS),
- treatment with intra-articular steroid injections and/or hyaluronic acid in the previous 3 months
- allergies to local anesthetics,
- connective tissue diseases affecting the knee,
- unwilling,
- unable to communicate in English,
- have acute knee pain,
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this clinical trial is to compare three-point and six-point Genicular Nerve Radiofrequency Ablation (GNRFA) in adults with chronic knee osteoarthritis (KOA). The main question it aims to answer is whether six- target GNRFA technique is more efficacious than standard three-target GNRFA technique in managing the pain and function of KOA. Consented patients who respond to a diagnostic block will be randomly assigned to either three-point or six-point GNRFA. Researchers will compare pain and function in these two groups.
The 2 groups in the trial
- Three-target GNRFA technique (T1)Existing treatment, for comparison
Radiofrequency ablation will target three of the genicular nerves: the superolateral genicular nerve, the superomedial genicular nerve, and the inferomedial genicular nerve.
Treatment: Radiofrequency ablation
- Six-target GNRFA technique (T2)Existing treatment, for comparison
Radiofrequency ablation will target six of the genicular nerves: the superolateral genicular nerve, the superomedial genicular nerve, the inferomedial genicular nerve, two branches from the nerve of vastus intermedius, and the recurrent fibular nerve
Treatment: Radiofrequency ablation
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Randomized Controlled Trial Comparing the Efficacy of a Three-Point Versus a Six-Point Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis
- Record updated
- 4 June 2026