Testing Tongue Swabs to Detect Tuberculosis at the Point of Care
Tests tongue swab-based molecular assays for tuberculosis in people aged 12 and older.
Plain-language title generated from the registry record
Registry title: Assessing Diagnostics At Point-of-care for Tuberculosis
Key facts
- Where
- Dasmariñas, PhilippinesSee the site
Where in Philippines
- De La Salle Medical and Health Sciences InstituteDasmariñas, PhilippinesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, San Francisco
- Trial code
- NCT05941052
- Record updated
- 2 September 2026
- Original description
Every year, more than 3 million people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Assessing Diagnostics At Point-of-care for Tuberculosis (ADAPT) study seeks to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests.Read full original descriptionShow less
Supporting, Mobilizing and Accelerating Research for Tuberculosis Elimination (SMART4TB)- Technical Area (TA) 1: Diagnostics- Assessing Diagnostics At Point-of-care for Tuberculosis (ADAPT)
Every year, more than 3 million people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Assessing Diagnostics At Point-of-care for Tuberculosis (ADAPT) study seeks to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests.
Inclusion: The investigators will include non-hospitalized adults (age ≥ 12 years) with either:; cough ≥2 weeks' duration, a commonly accepted criterion for identifying people with presumed pulmonary TB (to facilitate standardization across sites and comparison of test performance across sub-groups; OR; risk factors for which TB screening is recommended (HIV infection, self-reported close contact, history of mining work). People with risk factors will be included if they screen positive for TB based on WHO-recommended screening tools as specified below:; Positive TB screening definitions by risk factor:; People Living with Human Immunodeficiency Virus (PLHIV) (Risk Factor): C Reactive Protein (CRP) >5 mg/dL OR abnormal chest x-ray (CXR); Self-reported Close Contact (Risk Factor): abnormal CXR History of mining work (Risk Factor): abnormal CXR; The investigators will include health workers at each clinical site who are:; aged ≥18 years; AND; involved in routine TB testing (collecting specimens for or performing TB tests).
Exclusion: Have taken any medication with anti-mycobacterial activity (including fluoroquinolones) for any reason, within 2 weeks of study entry (to reduce false-negatives); Completed latent or active TB treatment within the past 12 months (to increase TB prevalence and reduce false-positive results, respectively); Reside >20km from the study site or are unwilling to return for follow-up visits; OR; Are unwilling to provide informed consent; Assessment of the usability of novel TB tests:; The investigators will exclude staff who are:; unwilling to provide informed consent.
Novel TB triage and diagnostic tests:.