Tests diet and exercise to prevent knee osteoarthritis in women with obesity
Tests diet, exercise and weight-loss maintenance to prevent knee arthritis in women.
Plain-language title generated from the registry record
Registry title: The Osteoarthritis Prevention Study
Key facts
- Where
- Sydney, AustraliaSee the site
Where in Australia
- University of SydneySydney, AustraliaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wake Forest University
- Trial code
- NCT05946044
- Record updated
- 23 July 2026
- Original description
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.Read full original descriptionShow less
The Osteoarthritis Prevention Study
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.
Inclusion: Female; BMI ≥ 30 kg/m2; An eligible knee will have no OA by xray and MRI; No or infrequent knee pain (< 15 days/month) in the same knee.
Exclusion: during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without surgical repair; symptomatic or severe coronary artery disease; type 1 diabetes; active treatment for cancer; unable to walk without a device; blindness; knee injection during the past 6 months; bilateral knee OA by x-ray Kellgren-Lawrence (KL) ≥ 2; bilateral knee OA by MRI; bilateral symptomatic knee OA (frequent bilateral knee pain > 15 days per month); BMI< 30.0 kg/m2; male sex; claustrophobia; contraindication to MRI including body weight > 300 lbs or knee coil does not fit; unwillingness or inability to change eating and physical activity habits due to environment; cannot speak and read English; planning to leave area > 2 months during the 48-month intervention period.