Tests diet and exercise to prevent knee osteoarthritis in women with obesity
Tests diet, exercise and weight-loss maintenance to prevent knee arthritis in women.
Plain-language title generated from the registry record
Registry title: The Osteoarthritis Prevention Study
Key facts
- Where
- Sydney, AustraliaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women aged 50 or older with obesity who have no knee osteoarthritis and no or only occasional knee pain. It tests diet, exercise and weight-loss maintenance to prevent knee osteoarthritis.
- Age
- 50 years or older
- Sex
- Women only
- Disease stage
- No osteoarthritis in the knee on x-ray and MRI; no or infrequent knee pain (fewer than 15 days a month) in the same knee
- Earlier treatment
- No knee injection in the past 6 months; no knee fracture or ligament or meniscus injury in the past 12 months
- Biomarker or test result
- BMI of 30 kg/m2 or higher
Main reasons for not taking part
- Severe or symptomatic coronary artery disease
- Cannot walk without a device
- Type 1 diabetes or active treatment for cancer
- Knee osteoarthritis in both knees (by x-ray, MRI or frequent pain)
- Cannot have an MRI (for example claustrophobia or body weight over 300 lbs (136 kg))
Read by machine on 12 November 2026.
Where in Australia
- University of SydneySydney, AustraliaContact: Frances DaleyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Wake Forest University
- Trial code
- NCT05946044
- Record updated
- 23 July 2026
- Original description
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.Read full original descriptionShow less
The Osteoarthritis Prevention Study
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.
Inclusion: Female; BMI ≥ 30 kg/m2; An eligible knee will have no OA by xray and MRI; No or infrequent knee pain (< 15 days/month) in the same knee.
Exclusion: during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without surgical repair; symptomatic or severe coronary artery disease; type 1 diabetes; active treatment for cancer; unable to walk without a device; blindness; knee injection during the past 6 months; bilateral knee OA by x-ray Kellgren-Lawrence (KL) ≥ 2; bilateral knee OA by MRI; bilateral symptomatic knee OA (frequent bilateral knee pain > 15 days per month); BMI< 30.0 kg/m2; male sex; claustrophobia; contraindication to MRI including body weight > 300 lbs or knee coil does not fit; unwillingness or inability to change eating and physical activity habits due to environment; cannot speak and read English; planning to leave area > 2 months during the 48-month intervention period.