Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
Key facts
- Who runs it
- Anna Stanhewicz, PhD
- Where
- Iowa City, United StatesSee the site
- Trial code
- Status
- Recruiting
- Phase
- Early phase 1
- People taking part
- 28 people, planned
- Started
- 1 Jul 2023
- Expected to end
- 1 Jun 2027
- Type of study
- Interventional, 3 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- Acetylcholine
- insulin aspart
- Record updated
- 29 July 2026
Who can take part
- Age
- 18 years to 50 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- female sex
- 18 -50 years old
- pregnancy history within 5 years of the study visit
- had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes
- or without a history of gestational diabetes
Who cannot take part
- statin or other cholesterol-lowering medication
- current antihypertensive medication
- skin diseases
- diagnosed or suspected hepatic or metabolic disease including diabetes
- history of preeclampsia or gestational hypertension
- allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs
- current tobacco/e-cigarette use
- current pregnancy
- body mass index <18.5 kg/m2
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Where in United States
- University of IowaIowa City, United StatesContact: Anna Stanhewicz, PhDTaking people
About the trial
What the trial wants to find out
The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.
The 3 groups in the trial
- local lactated Ringer's perfusionPlacebo, for comparison
lactated Ringer's is perfused through the microdialysis fiber to serve as the vehicle control
Treatment: Acetylcholine and insulin aspart
- local ascorbate perfusionTreatment being tested
local ascorbate is perfused through the microdialysis fiber to serve as the antioxidant experimental treatment
Treatment: Acetylcholine and insulin aspart
- local L-NAME perfusionTreatment being tested
local L-NAME is perfused through the microdialysis fiber to inhibit nitric oxide synthase
Treatment: Acetylcholine and insulin aspart
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Role of Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
- Fit questions
- Built from NCT05946785, who can take part
- Record updated
- 29 July 2026