Compares how men and women with psoriatic arthritis respond to advanced therapies
Studies how sex and gender affect treatment response in adults with psoriatic arthritis.
Plain-language title generated from the registry record
Registry title: Sex and Gender-based Analysis of the Effectiveness of Advanced Therapies in Psoriatic Arthritis
Key facts
- Where
- Toronto, CanadaSee the site
Where in Canada
- Women's College HospitalToronto, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Women's College Hospital
- Trial code
- NCT05954364
- Record updated
- 24 July 2023
- Original description
Sex and gender are important factors that influence treatment response in PsA. The goal of this multi-centre observational study is to understand how sex and gender influence response to advanced therapies in psoriatic arthritis (PsA). The investigators hope to discover biological and socio-cultural mechanisms that explain the differences in treatment response between men and women with PsA.Read full original descriptionShow less
Sex Matters: Sex- And Gender-based Analysis of the Effectiveness of Advanced Therapies in Psoriatic Arthritis (SAGE-PsA) - an International Multicentre Study
Sex and gender are important factors that influence treatment response in PsA. The goal of this multi-centre observational study is to understand how sex and gender influence response to advanced therapies in psoriatic arthritis (PsA). The investigators hope to discover biological and socio-cultural mechanisms that explain the differences in treatment response between men and women with PsA.
The study investigators plan to recruit patients from approximately 30 sites across the world. Men and women with active PsA will be assessed before and after they start advanced therapies and information will be collected about sex- and gender-related factors through questionnaires and physical examination. Physicians will assess the patient response to treatment. The investigators will compare the response to treatment in men and women and assess what biological and socio-cultural factors contribute to differences in treatment response.
Inclusion: Rheumatologist confirmed diagnosis of PsA according to CASPAR criteria; Age ≥18 years; Active PsA with any of the following manifestations detected on physical examination: peripheral arthritis, dactylitis, and enthesitis. The patient may have axial involvement in addition to the peripheral manifestations of PsA; Plan to start treatment with advanced therapies for peripheral musculoskeletal manifestations of PsA.
Exclusion: The drug is given for another indication and not for active PsA (e.g. psoriasis, IBD); Unable to read or write; Unable to sign informed consent; Cannot return for a follow up visit; Pregnant women.