Electric stimulation for memory problems in relapsing-remitting multiple sclerosis
Tests low-level brain electric stimulation to improve word recall in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation
Key facts
- Where
- Richardson, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT05958381, who can take part
Where in United States
- The University of Texas at DallasRichardson, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The University of Texas at Dallas
- Trial code
- NCT05958381
- Record updated
- 15 September 2026
- Original description
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.Read full original descriptionShow less
Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.
Inclusion: º Diagnosed with relapsing-remitting multiple sclerosis (RRMS); º Memory retrieval deficit based on neuropsychological testing done in our lab; º Must be fluent in speaking and reading English.
Exclusion: º Relapse or acute MS exacerbation or a course of steroids in the two months preceding the testing; present drug abuse; º Potentially confounding psychological or neurological disorder, including:; dementia of any type; epilepsy or other seizure disorders; stroke; Parkinson's disease; Huntington's disease; º inability to give informed consent; º cranial implants; º skull defects that affect tDCS administration; º use of medications that interact with or potentially interact with tDCS effects, including:; º Participants using benzodiazepines must have been on a stable dose for at least two months; severe traumatic brain injury; brain tumor; blood vessel abnormalities in the brain; anti-convulsants; L-dopa; carbamazepine; sulpiride; pergolide; lorazepam; rivastigmine; dextromethorphan; D-cycloserine; flunarizine; ropinirole; stimulants (dextroamphetamine/amphetamine/modafinil/armodafinil) must be stopped during enrollment.