Blood pressure monitoring measures and low blood pressure during surgery in hypertensive patients
Studies whether blood pressure recording measures predict low blood pressure in adults having major surgery.
Plain-language title generated from the registry record
Registry title: Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Key facts
- Where
- Ankara, Erzurum, Istanbul, and Rize, TürkiyeSee the 5 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having major surgery under general anesthesia who are at risk of low blood pressure after anesthesia starts, for example because of high blood pressure or diabetes.
- Age
- 18 years or older
- Sex
- Men and women can join
- Disease stage
- People having major surgery expected to last more than 2 h, with a hospital stay of more than 2 d after surgery. They have a reason for a passive leg raising test, such as risk of low blood volume, expected blood loss, or heart and blood vessel conditions.
- Earlier treatment
- People who need a drip of heart or blood pressure drugs (inotrope/vasopressor) before surgery, or who take drugs that act on blood vessels, cannot join.
Main reasons for not taking part
- Irregular heart rhythm (cardiac arrhythmia)
- Heart failure NYHA class 3-4, or ejection fraction below 35%
- Kidney filtration rate below 30 ml/min/1.73 m2, or ongoing renal replacement therapy
- Unstable blood pressure (mean arterial pressure below 65 mmHg)
- Needing intensive care before surgery, or fitted with an intra-aortic balloon pump or ECMO
Read by machine on 12 November 2026.
Where in Türkiye
- Gazi University Medical Faculty, Department of Anesthesiology and ReanimationAnkara, TürkiyeContact: Aycan Özdemirkan, Assoc. Prof.Taking people
- Erzurum Atatürk University Medical Faculty, Department of Anesthesiology and ReanimationErzurum, TürkiyeContact: Enes Aydın, Assoc. Prof.Taking people
- Acıbadem University Medical Faculty, Department of Anesthesiology and ReanimationIstanbul, TürkiyeContact: Fevzi Toraman, Prof. Dr.Taking people
- Başakşehir Çam ve Sakura City Hospital, University Medical Faculty, Anesthesiology and Reanimation ClinicIstanbul, TürkiyeContact: Taner Abdullah, Asst. ProfTaking people
- Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and ReanimationRize, TürkiyeContact: Başar Erdivanlı, Assoc. Prof.Not yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Recep Tayyip Erdogan University
- Trial code
- NCT05960604
- Record updated
- 9 April 2025
- Original description
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy) of the MostCare system, specifically cardiac cycle efficiency has been proposed as such variables. Yet, their value in anesthesia and especially in hypertensive patients is not studied. The goal of the PRAM-in-HYPO study is to prospectively evaluate the relationship between cardiac reserve and efficiency and cardiovascular risk factors in patients wo will undergo major surgical procedures using the state-of-the-art hemodynamic monitors. Also the investigators aim to build a predictive model to identify patients with decreased cardiac reserve due to hypertension and other cardiovascular risk factors, who are susceptible to post-induction hypotension. The investigators seek to include high-risk patients or patients presenting for major surgery, who are monitored with an advanced hemodynamic monitor to adequately evaluate the differences in cardiac reserve and cardiac efficiency.Read full original descriptionShow less
Observational Study to Evaluate the Pressure Recording Analytical Method Parameters in Patients Susceptible to Post-induction Hypotension Due to Hypertension, Diabetes Mellitus, Cardiovascular Risk Factors, or Major Surgery
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy) of the MostCare system, specifically cardiac cycle efficiency has been proposed as such variables. Yet, their value in anesthesia and especially in hypertensive patients is not studied. The goal of the PRAM-in-HYPO study is to prospectively evaluate the relationship between cardiac reserve and efficiency and cardiovascular risk factors in patients wo will undergo major surgical procedures using the state-of-the-art hemodynamic monitors. Also the investigators aim to build a predictive model to identify patients with decreased cardiac reserve due to hypertension and other cardiovascular risk factors, who are susceptible to post-induction hypotension. The investigators seek to include high-risk patients or patients presenting for major surgery, who are monitored with an advanced hemodynamic monitor to adequately evaluate the differences in cardiac reserve and cardiac efficiency.
Inclusion: Age at least 18 years; Undergoing major surgery under general anesthesia; Expected surgery time >2 h; Expected length of postoperative stay >2 d; Invasive blood pressure (radial or femoral) and Mostcare monitoring; Indication for a passive leg raising test: risk of hypovolemia (preoperative fasting, bowel preparation, loss of appetite, limited access to water) or expected major surgery, expected blood loss, cardiovascular comorbidity (hypertension, diabetes mellitus, coronary artery disease, peripheral artery disease, hyperlipidemia, morbidity, active smoking); Recruitment after booking for surgery with sufficient time to read, understand and question study patient information prior to attending for surgery; Ability and willingness to provide informed consent.
Exclusion: Preoperatively receiving vasoactive drugs; Ongoing renal replacement therapy; Cardiac arrhythmia; Presence of intraabdominal hypertension; New York Heart Association Class 3-4 heart failure; Congestive heart failure with ejection fraction < 35%; Refuse to consent to the study; Arterial wave form distortion; Inappropriate identification of the dicrotic notch for any reason; Planned intraoperative mean arterial blood pressure < 65 mmHg; Hemodynamic instability defined as mean arterial blood pressure < 65 mmHg; Preoperative requirement of inotrope/vasopressor infusion; Patients fitted with an intra-aortic balloon pump; Patients fitted with Extracorporeal Membrane Oxygenation; Critically ill patients requiring preoperative intensive care unit; Glomerular filtration rate < 30 ml/min/1.73 m2.