Two nerve treatments for long-lasting knee osteoarthritis pain compared
Compares two nerve procedures for pain and movement in people with knee osteoarthritis.
Key facts
- Who runs it
- University Medical Centre Ljubljana
- Where
- Ljubljana, SloveniaSee the site
- Trial code
- Registry title
- Pulsed Radiofrequency Therapy vs Canal Adductor Blockade in Knee Osteoarthritis
- Status
- Recruiting
- People taking part
- 128 people, planned
- Started
- 9 Oct 2024
- Planned end
- Jun 2025
- Type of study
- Observational, 2 groups
- Treatments tested
- Canal adductor blockade
- Canal adductor pulsed radio-frequency therapy
- Record updated
- 9 December 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults over 45 with knee osteoarthritis (wear-and-tear arthritis of the knee) and long-lasting knee pain. It compares two nerve treatments for knee pain.
- Age
- Older than 45 years, up to 100 Years
- Sex
- All sexes can join
- Disease stage
- Knee osteoarthritis confirmed by an orthopedic examination, K-L grade 3 or 4 (advanced joint damage on X-ray)
- Earlier treatment
- People who have taken opioid painkillers for more than 3 months at more than 30 mg of daily oral morphine equivalents cannot join
Main reasons for not taking part
- Heart, liver or kidney conditions that the investigator thinks would affect taking part
- Severe nerve conditions, psychiatric illnesses, or severe blood disorders or clotting problems
- Allergy to any of the drugs used in the study
- Infection or cancer at the injection site, or any active infection in the body
- Implanted electronic devices, such as spinal cord stimulators or cardiac pacemakers
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Diagnose of the Knee osteoarthritis confirmed by orthopedic examination
- K-L grades 3 and 4
- A sufficient level of education to understand study procedures
- Be able to communicate with site personnel
- Age >45 years
Who cannot take part
- Any cardiovascular, hepatic, or renal conditions that would compromise participation, in the opinion of the investigator
- Severe neurologic conditions interfere with a knee condition
- Coexisting severe hematological disorder or deranged coagulation parameters
- Psychiatric illnesses
- Allergy to any of the drugs used in the study
- Infection or malignancy at the site of the block
- Any active systemic infection
- Implanted electronic devices like spinal cord stimulators, cardiac pacemakers or similar
- Narcotic dependent (opioid intake of more than 3 months and more than 30 mg of daily oral morphine equivalents)
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 100 years old?
Where in Slovenia
- University Medical CentreLjubljana, SloveniaContact: Mensur SalihovicTaking people
About the trial
What the trial wants to find out
This study is intended to prove the efficacy and safety of ultrasound-guided pulsed radiofrequency therapy on adductor canal nerves by patients with Knee osteoarthritis.
The 2 groups in the trial
- Canal adductor blockade
After surgical cleaning of the anteromedial thigh, all participants in this group received single shot ultrasound guided canal adductor blockade with 14 ml 0,25% levobupivacaine and 100 mcg clonidine mixed in the same syringe. Investigators previously scanned the adductor canal and chose the middle of the canal as the entry point of the 10 cm echogenic ultrasound needle. After the blockade, all participants were monitored in our ambulance for the next hour.
- Pulsed radiofrequency therapy
After surgical cleaning of the anteromedial thigh, all participants in this group received ultrasound-guided pulsed radiofrequency therapy. Investigators previously scanned the adductor canal and chose the middle of the canal as the entry point of the RF 10 cm needle with a 1 cm free tip. After sensory and motor checking all patients have gotten 6 minutes of therapy divided into 3 sequences of 2 minutes of 50 V current and 42. Before starting the PRF therapy all participants have gotten 2 ml 0,25% levobupivacaine through the needle for preventing discomfort during the procedure. After the treatment, all participants were monitored in our ambulance for the next hour.
Treatment: Canal adductor pulsed radio-frequency therapy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparison of the Effectiveness of Pulsed Radiofrequency Therapy and Canal Adductor Blockade for Chronic Pain and Functioning in Knee Osteoarthritis
- Plain-language title
- Two nerve treatments for long-lasting knee osteoarthritis pain comparedGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Fit questions
- Built from NCT05962463, who can take part
- Record updated
- 9 December 2024