NCT05978804Terminated
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
Remote Home-based Electrical Stimulation (tDCS) in Primary Progressive Aphasia (With Frontotemporal Dementia or Alzheimer's Pathology) and Mild Cognitive Impairment/Alzheimer's.
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild cognitive impairment (MCI), or dementia. In this study, investigators will use transcranial direct current stimulation (tDCS) to stimulate the left dorsolateral prefrontal cortex (DLPFC). Previous studies have demonstrated that tDCS over the DLPFC led to improvements in attention deficit caused by stroke, Parkinson's Disease, and major depression as well as language deficits caused by neurodegenerative conditions such as primary progressive aphasia or mild cognitive impairment. The investigators seek to expand on this literature by investigating how anodal tDCS paired with and without cognitive training will impact executive functioning in PPA with Frontotemporal Dementia or Alzheimer's Disease pathology and Mild Cognitive Impairment/Alzheimer's Disease (e.g. shifting, updating, monitoring, and manipulation).
- Status (registry)
- Terminated
- Study type
- Interventional
- Enrollment
- 5 (actual)
- First submitted
- 11 Jul 2023
- Start date
- 10 Aug 2023
- Primary completion date
- 10 Sept 2025
- Lead sponsor
- Johns Hopkins University
- Diseases
- Frontotemporal dementia, Alzheimer disease
- NCT number
- NCT05978804
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncorrected visual or hearing impairment by self-report.
- Stroke/other premorbid neurological disorder affecting the brain.
- Any other developmental language-based learning disorder other than PPA.
- Pre-existing psychiatric disorders such as behavioral disturbances, severe depression, and schizophrenia that do not allow them to comply or follow the study schedule and requirements such as repeated evaluation and therapy will be excluded.
- Cardiac pacemakers or ferromagnetic implants.
Other
- Inability to follow directions for baseline tasks.
- Severe claustrophobia.
- Pregnant women.
Who the study is looking for
- Must be clinically diagnosed with PPA, fronto-temporal dementia (FTD), MCI or mild Alzheimer's disease (AD). Diagnosis will be based on neuropsychological testing, language testing (most commonly the Western Aphasia Battery), MRI, and clinical assessment.
- Must be right-handed.
- Must be proficient in English.
- Must have a minimum high-school education.
Age in the registry: 50 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins University | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.