Elemental Diet and Gut Microbiome

Who can take part

• • Participant must be able to understand and provide informed consent; Males and Females ≥18-85; Female subjects of childbearing potential must have a negative pregnancy test upon study entry; Female (and male) subjects with reproductive potential, must agree to use FDA approved methods of birth control for the duration of the study; Subject self-reports experiencing SIBO symptoms within 30 days; Positive (abnormal) lactulose breath test for SIBO on visit 1 (day -7) as defined as:; Rise of hydrogen ≥ 20ppm within 90 minutes on LBT OR; A methane level ≥10 ppm at any point during the 120-minute LBT

Who cannot take part

• • Inability or unwillingness of a participant to give written informed consent or comply with study protocol; Pregnancy or lactating; Type 1 or type 2 diabetes; Active or ongoing infection that requires antibiotics other than the participants known prophylactic medications (i.e. active infection or antibiotic use in the last 1 month); Any condition that, in the opinion of the investigator, contraindicates participation in this study will be excluded from study participation; History of known Phenylketonuria (PKU) disease; Non-English-speaking participants