Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
Key facts
- Who runs it
- ART Fertility Clinics LLC
- Where
- United Arab Emirates2 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Suspended
- Phase
- Phase 1
- People taking part
- 316 people, planned
- Started
- 22 Sept 2023
- Expected to end
- 30 Dec 2026
- Type of study
- Interventional, 2 groups
- Treatments tested
- Transvaginal ultrasound
- Serum LH, E2, P4
- Estradiol Valerate 2 MG
- Progesterone 100 Mg Vaginal Insert
- Serum P4 day of ET
- Embryo transfer
- Record updated
- 25 June 2026
- Why it stopped
- Difficulty of enrolling and recruiting patients
Who can take part
- Age
- 18 years to 43 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Women aged 18 years to 43 years
- Having at least 1 euploid cryopreserved day 6 blastocyst of at least Grade BB quality
- Endometrial trilaminar appearance on the day of progesterone start
Who cannot take part
- Intention to treat : exclusion factors :; Spontaneous ovulation HRT cycle; Discontinuation of HRT medication
- Asherman syndrome
- Any known contraindications or allergy to oral estradiol or progesterone
- Uterine abnormality
- Hydrosalpinx
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this study is to compare the difference in clinical pregnancy, miscarriage and livebirth rate between day 6 euploid blastocyst transfer on the 6th and the 7th day of progesterone exposure in Hormonal Replacement Therapy (HRT) FET cycles. This prospective \& randomized study will only include euploid day 6 blastocysts. This will be the first prospective study of euploid day 6 blastocysts thereby excluding aneuploidy as a cause of miscarriage and implantation failure. The point of randomization will occur on the day of progesterone commencement.
The 2 groups in the trial
- Group AOther group
Embryo transfer is scheduled on the 6th full day of progesterone administration, following the initial commencement of progesterone (120 hours)
Treatment: Transvaginal ultrasound, Serum LH, E2, P4, Estradiol Valerate 2 MG, Progesterone 100 Mg Vaginal Insert, Serum P4 day of ET, and Embryo transfer
- Group BOther group
Embryo Transfer is scheduled on the 7th full day of progesterone administration, following the initial commencement of progesterone (144 hours)
Treatment: Transvaginal ultrasound, Serum LH, E2, P4, Estradiol Valerate 2 MG, Progesterone 100 Mg Vaginal Insert, Serum P4 day of ET, and Embryo transfer
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Optimal Timing of Euploid Day 6 Blastocyst (Blastocyst Which Was Biopsied on Day 6 After Fertilization) Transfer in Frozen Hormonal Replacement Therapy Cycles: Day 6 or Day 7 of Progesterone Administration?
- Record updated
- 25 June 2026