Comparing two spinal implant cages in people with osteoporosis and lumbar spine disease
Compares titanium and PEEK spinal cages in adults over 50 with osteoporosis.
Plain-language title generated from the registry record
Registry title: Osteo Match Cages Versus PEEK Cages in Osteoporotic Patients
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 or older with osteoporosis and a degenerative lumbar spine disease who need lumbar fusion surgery with cages. It compares two types of cage.
- Age
- 50 years or older
- Sex
- All sexes can join.
- Disease stage
- Degenerative lumbar disease (such as spinal stenosis or spondylolisthesis) needing fusion with pedicle screws, plus osteoporosis shown by a bone density test. Cages are needed within L3-S1.
- Earlier treatment
- No response to at least 3 months of treatment without surgery. No earlier lumbar fusion surgery.
- Biomarker or test result
- Osteoporosis diagnosed by any bone density method, such as DXA, QCT or CT Hounsfield units.
Main reasons for not taking part
- Surgery plan with extra fixation methods, such as bone cement on the screws
- Spondylolisthesis of grade II or higher
- Scoliosis over 20° or unbalanced spine alignment
- Fracture of a vertebra in the fused segment
- ASA grade IV or higher
Read by machine on 9 November 2026.
Where in China
- Peking University Third HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Peking University Third Hospital
- Trial code
- NCT05981222
- Record updated
- 22 January 2025
- Original description
This is a multicenter, prospective cohort study. The osteoporotic patients requiring posterior lumbar interbody fusion(LIF) with cages are prospectively enrolled and followed up. The patients undergoing LIF with the biomechanical-matched 3D-printed titanium cages (Osteo Match) are compared with those using routine PEEK cages. The hypothesis is that the use of Osteo Match cages can reduce the rate of cage subsidence and increase the rate of lumbar fusion in osteoporotic patients.Read full original descriptionShow less
Biomechanical-matched Titanium Cages(Osteo Match) Versus PEEK Cages in Osteoporotic Lumbar Spine: a Multicenter, Prospective Cohort Study
This is a multicenter, prospective cohort study. The osteoporotic patients requiring posterior lumbar interbody fusion(LIF) with cages are prospectively enrolled and followed up. The patients undergoing LIF with the biomechanical-matched 3D-printed titanium cages (Osteo Match) are compared with those using routine PEEK cages. The hypothesis is that the use of Osteo Match cages can reduce the rate of cage subsidence and increase the rate of lumbar fusion in osteoporotic patients.
Inclusion: aged≥ 50 years old; lumbar degenerative diseases requiring lumbar fusion with pedicle screw fixation, such as degenerative lumbar spinal stenosis, degenerative lumbar spondylolisthesis; no response to nonoperative treatment of at least 3 months; osteoporosis diagnosed by any method for bone mineral density evaluation, such as DXA, QCTor CT Hounsfield units; requiring lumbar interbody fusion with cages within L3-S1; the type of fusion cage has been chosen by the patients; informed consent.
Exclusion: the surgical plan includes any unconventional techniques used to strengthen the fixation, such as augmentation of the pedicle screw with bone cement; history of lumbar fusion surgery; cervical myelopathy, thoracic spinal stenosis, motor neuron disease,tuberculosis of spine,spinal tumor; lumbar spondylolisthesis of ≥II degree; lumbar scoliosis of >20° or imbalance of spinal alignment; vertebral fracture within interbody fusion segement; ASA of ≥IV.