Tests added docetaxel with rezvilutamide in men with advanced prostate cancer
Tests adding docetaxel to rezvilutamide and hormone therapy in metastatic prostate cancer.
Plain-language title generated from the registry record
Registry title: Comparing the Efficacy and Safety of Rezvilutamide+ADT+Docetaxel Versus Rezvilutamide +ADT in the mHSPC
Key facts
- Where
- Nanjing, ChinaSee the site
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT05983783, who can take part
Where in China
- Urology dpt, First Affiliated Hospital of Nanjing Medical UniversityNanjing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The First Affiliated Hospital with Nanjing Medical University
- Trial code
- NCT05983783
- Record updated
- 9 August 2023
- Original description
Evaluate whether the combination of Rezvilutamide and androgen deprivation therapy (ADT) with docetaxel improves overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) compared to the combination of Rezvilutamide and ADT.Read full original descriptionShow less
A Prospective Randomized Controlled Study Comparing the Efficacy and Safety of Rezvilutamide+ADT+Docetaxel Versus Rezvilutamide +ADT in the Treatment of Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Evaluate whether the combination of Rezvilutamide and androgen deprivation therapy (ADT) with docetaxel improves overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) compared to the combination of Rezvilutamide and ADT.
Inclusion: Males aged ≥40 years and ≤80 years; Histologically or cytologically confirmed prostate adenocarcinoma; Metastatic disease; Eligible for ADT and Docetaxel; Started or not started first-generation androgen deprivation therapy (ADT), but not exceeding 12 weeks before randomization; ECOG score of 0 or 1; Laboratory tests meet the following requirements:; Hematology: neutrophils ≥1.5×10\^9/L, platelets ≥100×10\^9/L, hemoglobin ≥9g/dL; Renal function: serum creatinine ≤1.5× upper limit of normal (ULN); Liver function: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5× ULN, total bilirubin (TBIL) ≤1.5× ULN; Coagulation function: international normalized ratio (INR) <1.5; Study subjects: Patients with mHSPC have a confirmed pathology of prostate adenocarcinoma with high tumor burden, which is defined by having at least one of the following conditions:; Bone scan showing ≥4 bone metastatic lesions (with at least one site outside the pelvis or spine); CT/MRI revealing visceral metastatic lesions (excluding lymph nodes).
Exclusion: Prior use of LHRH agonists/antagonists; second-generation androgen receptor (AR) inhibitors such as enzalutamide, ARN-509, darolutamide (ODM-201), or other investigational AR inhibitors; CYP17 enzyme inhibitors such as abiraterone acetate or oral ketoconazole for anti-tumor treatment of prostate cancer; chemotherapy or immunotherapy for prostate cancer prior to randomization; Received radiation therapy/radiopharmaceutical treatment within 2 weeks before randomization; Any of the following conditions within 6 months before randomization: stroke, myocardial infarction, severe/unstable angina pectoris, coronary artery/peripheral artery bypass surgery, congestive heart failure (New York Heart Association class III or IV); Inability to take oral medication; Previous malignancy, except adequately treated basal cell carcinoma or squamous cell carcinoma of the skin or superficial bladder cancer not invading the deeper muscle layer (i.e., pTis, pTa, and pT1) and any other cancer in complete remission for at least 5 years before randomization; Gastrointestinal diseases or procedures that are expected to significantly interfere with the absorption of study treatment; Patients who meet any of the following criteria are not eligible to participate in this study:.