Daytime Body Rhythms in Breath Chemicals of People With and Without Diabetes
Measures breath chemicals during the day in adults with and without diabetes.
Key facts
- Who runs it
- University of Bern
- Where
- Bern, SwitzerlandSee the site
- Trial code
- Registry title
- The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes
- Status
- Recruiting
- People taking part
- 60 people, planned
- Started
- 7 Aug 2023
- Planned end
- 30 Jun 2026
- Type of study
- Observational, 3 groups
- Treatments tested
- Standardized meal
- Record updated
- 8 December 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults without diabetes, adults with type 1 diabetes, and adults with type 2 diabetes. It measures compounds in exhaled breath during the day.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Three groups: no diabetes (HbA1c below 6.5% (48 mmol/mol)); type 1 diabetes on multiple daily injections or an insulin pump for more than 1 year; type 2 diabetes on tablets or insulin.
- Earlier treatment
- People with type 1 diabetes must have used multiple daily injections or an insulin pump for more than 1 year. People with type 2 diabetes use tablets or insulin. No antibiotics in the previous 4 months.
- Biomarker or test result
- People without diabetes must have an HbA1c below 6.5% (48 mmol/mol).
Main reasons for not taking part
- Pregnancy or breastfeeding
- Smoking (last cigarette less than 6 months ago)
- Chronic lung or bowel disease, such as asthma, COPD, IBD or lung cancer
- Coeliac disease, or lactose or fructose intolerance
- More than four units of alcohol per day
The registry criteria, word for word
Show all 19 criteriaShow less
Who can take part
- Subgroup 1:
- Age 18 or older
- HbA1c below 6.5%
- Written informed consent; Subgroup 2:
- Age 18 or older
- T1D (Type 1 diabetes) with MDI (multiple daily injection) or CSII (Continuous subcutaneous insulin infusion therapy) therapy >1 year
- Written informed consent; Subgroup 3
- Age 18 or older
- T2D (Type 2 diabetes) with oral antidiabetic medication or insulin therapy
- Written informed consent
Who cannot take part
- Antibiotic treatment in the previous 4 months
- Any chronical lung and intestinal disease diagnosis (such as intestinal bowel disease (IBD); asthma; COPD (chronic obstructive pulmonary disease); lung cancer, …)
- Coeliac disease
- Any acute disease diagnosis (such as viral or bacterial infection)
- Pregnancy or breastfeeding
- Smoking (last cigarette less than 6 months ago)
- Lactose and fructose intolerance
- Drinking habit of more than four units of alcohol per day
- Current inhaled medicines treatments
Where in Switzerland
- University of BernBern, SwitzerlandContact: Witthauer Lilian, Prof.Dr.Taking people
About the trial
What the trial wants to find out
Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.
The 3 groups in the trial
- People without diabetes
Treatment: Standardized meal
- People with type 1 diabetes
Treatment: Standardized meal
- People with type 2 diabetes
Treatment: Standardized meal
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and With Type 1 and 2 Diabetes: an Exploratory Study
- Plain-language title
- Daytime Body Rhythms in Breath Chemicals of People With and Without DiabetesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Publications
- Record updated
- 8 December 2025