Which factors before surgery predict weight loss for people with severe obesity
Studies which pre-surgery factors predict weight loss in adults with severe obesity.
Plain-language title generated from the registry record
Registry title: Predictors of Weight Loss and Metabolic Health After Bariatric Surgery
Key facts
- Where
- Gouda, Nieuwegein, and The Hague, NetherlandsSee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT05987631, who can take part
Where in Netherlands
- Nederlandse Obesitas Kliniek GoudaGouda, NetherlandsNot yet recruiting
- Nederlandse Obesitas Kliniek NieuwegeinNieuwegein, NetherlandsNot yet recruiting
- Nederlandse Obesitas Kliniek Den HaagThe Hague, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Trial code
- NCT05987631
- Record updated
- 14 August 2023
- Original description
In this prospective study the investigators aim to identify preoperative predictors of improvement of metabolic health and weight loss after bariatric surgery focusing on inflammation, insulin sensitivity (in a subgroup of patients), glucoregulatory determinants, psychological traits, feeding behavior characteristics and cardiorespiratory fitnessRead full original descriptionShow less
Preoperative Predictors of Weight Loss and Improved Metabolic Health After Bariatric Surgery
In this prospective study the investigators aim to identify preoperative predictors of improvement of metabolic health and weight loss after bariatric surgery focusing on inflammation, insulin sensitivity (in a subgroup of patients), glucoregulatory determinants, psychological traits, feeding behavior characteristics and cardiorespiratory fitness
Inclusion: Ability to provide informed consent; Patient is ≥ 18 and ≤ 75 years old; BMI ≥ 40 kg/m2 or ≥ 35 kg/m2 with obesity related comorbidity; Scheduled for primary bariatric procedure: Roux-en-Y gastric bypass (RYGB) or Sleeve Gastrectomy (SG); Stable weight 3 months prior to inclusion weight (<10% change in body weight for 3 months prior to assessments); In order to be eligible to participate in the subgroup of this study, we will use the following inclusion criteria:; Ability to provide informed consent; Patient is ≥ 18 and ≤ 75 years old; BMI ≥ 40 kg/m2 or ≥ 35 kg/m2 with obesity related comorbidity; Patients scheduled for RYGB; Patients who are insulin resistant (impaired fasting glucose (> 5.6 mmol/L) or fasting insulin > 74 pmol/L); Postmenopausal women (to prevent bias due to the effect of sex hormones on insulin sensitivity).
Exclusion: Pregnancy anticipated in the first two years following surgery; A potential subject who meet the following criteria will be excluded from participation in the subgroup of this study:; Use of any medication except for statins, antihypertensives (except for Angiotensine converting enzyme (ACE)- or angiotensin receptor blockers) and thyroid hormone; Any actual medical condition except for obesity related health issues or well treated hypothyroidism; Coagulation disorders and/or use anticoagulants; Diabetes mellitus type 2.