Changes in Inhibition and Valuation After Eating
Key facts
- Who runs it
- Icahn School of Medicine at Mount Sinai
- Where
- New York, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 150 people, planned
- Started
- 12 Dec 2023
- Expected to end
- 31 Dec 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Fasting state
- Fed state
- Magnetic Resonance Imaging
- Record updated
- 17 February 2026
Who can take part
- Age
- 18 years to 45 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Female
- Aged 18 to 45 years
- Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2
- Right-handed
- English-speaking; Additional Inclusion Criteria for Women with Bulimia Nervosa:
- Meet DSM-5 criteria for bulimia nervosa
Who cannot take part
- Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation
- Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period
- Medical instability
- Shift work
- Pregnancy, planned pregnancy, or lactation during the study period
- Any contraindication for fMRI
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Where in United States
- Center of Excellence in Eating and Weight Disorders at the Icahn School of Medicine at Mount SinaiNew York, United StatesContact: Jiulin Dai, B.S.Taking people
About the trial
What the trial wants to find out
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.
The 2 groups in the trial
- Participants with Bulimia NervosaTreatment being tested
Participants are randomly assigned (in even numbers across the two groups) to scan order: A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day. B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.
Treatment: Fasting state, Fed state, and Magnetic Resonance Imaging
- Participants without Bulimia NervosaExisting treatment, for comparison
Participants are randomly assigned (in even numbers across the two groups) to scan order: A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day. B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.
Treatment: Fasting state, Fed state, and Magnetic Resonance Imaging
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa
- Fit questions
- Built from NCT05995496, who can take part
- Record updated
- 17 February 2026